KCNA2

Potassium voltage-gated channel, shaker-related subfamily, member 2, also known as KCNA2 or K_v1.2, is a human gene.cite web | title = Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3737| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.cite web | title = Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3737| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Paulmichl M, Nasmith P, Hellmiss R, "et al." |title=Cloning and expression of a rat cardiac delayed rectifier potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7892–5 |year= 1991 |pmid= 1715584 |doi=
*cite journal | author=Grissmer S, Dethlefs B, Wasmuth JJ, "et al." |title=Expression and chromosomal localization of a lymphocyte K+ channel gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9411–5 |year= 1991 |pmid= 2251283 |doi=
*cite journal | author=McKinnon D |title=Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. |journal=J. Biol. Chem. |volume=264 |issue= 14 |pages= 8230–6 |year= 1989 |pmid= 2722779 |doi=
*cite journal | author=Kim E, Niethammer M, Rothschild A, "et al." |title=Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. |journal=Nature |volume=378 |issue= 6552 |pages= 85–8 |year= 1995 |pmid= 7477295 |doi= 10.1038/378085a0
*cite journal | author=Klocke R, Roberds SL, Tamkun MM, "et al." |title=Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. |journal=Genomics |volume=18 |issue= 3 |pages= 568–74 |year= 1994 |pmid= 7905852 |doi=
*cite journal | author=Ramaswami M, Tanouy M, Mathew MK |title=Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs. |journal=Indian J. Biochem. Biophys. |volume=31 |issue= 4 |pages= 254–60 |year= 1995 |pmid= 8002006 |doi=
*cite journal | author=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084–9 |year= 1996 |pmid= 8636142 |doi=
*cite journal | author=Adda S, Fleischmann BK, Freedman BD, "et al." |title=Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13239–43 |year= 1996 |pmid= 8662756 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kim E, Sheng M |title=Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. |journal=Neuropharmacology |volume=35 |issue= 7 |pages= 993–1000 |year= 1997 |pmid= 8938729 |doi=
*cite journal | author=Cachero TG, Morielli AD, Peralta EG |title=The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. |journal=Cell |volume=93 |issue= 6 |pages= 1077–85 |year= 1998 |pmid= 9635436 |doi=
*cite journal | author=Tsai W, Morielli AD, Cachero TG, Peralta EG |title=Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity. |journal=EMBO J. |volume=18 |issue= 1 |pages= 109–18 |year= 1999 |pmid= 9878055 |doi= 10.1093/emboj/18.1.109
*cite journal | author=Coleman SK, Newcombe J, Pryke J, Dolly JO |title=Subunit composition of Kv1 channels in human CNS. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 849–58 |year= 1999 |pmid= 10428084 |doi=
*cite journal | author=D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M |title=Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function. |journal=FASEB J. |volume=13 |issue= 11 |pages= 1335–45 |year= 1999 |pmid= 10428758 |doi=
*cite journal | author=Wade GR, Laurier LG, Preiksaitis HG, Sims SM |title=Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction. |journal=Am. J. Physiol. |volume=277 |issue= 4 Pt 1 |pages= G885–95 |year= 1999 |pmid= 10516156 |doi=
*cite journal | author=Poliak S, Gollan L, Martinez R, "et al." |title=Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. |journal=Neuron |volume=24 |issue= 4 |pages= 1037–47 |year= 2000 |pmid= 10624965 |doi=
*cite journal | author=Manganas LN, Trimmer JS |title=Subunit composition determines Kv1 potassium channel surface expression. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29685–93 |year= 2000 |pmid= 10896669 |doi= 10.1074/jbc.M005010200
*cite journal | author=Kuryshev YA, Wible BA, Gudz TI, "et al." |title=KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 1 |pages= C290–9 |year= 2001 |pmid= 11401852 |doi=
*cite journal | author=Byron KL, Lucchesi PA |title=Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7298–307 |year= 2002 |pmid= 11739373 |doi= 10.1074/jbc.M104726200

External links

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