IHH

Indian hedgehog homolog (Drosophila), also known as IHH, is a human gene.cite web | title = Entrez Gene: IHH Indian hedgehog homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3549| accessdate = ] The Indian Hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and Sonic hedgehog (SHH). It is involved in Chondrocyte differentiation, proliferation and maturation especially during Endochondral ossification. It regulates it's effects by feedback control of parathyroid hormone-related peptide (PTHrP).

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References

Further reading

* St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999 Aug 15;13(16):2072-86. Erratum in: Genes Dev 1999 Oct 1;13(19):2617.
* Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development. 2000 Feb;127(3):543-8.
*Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development. 2001 Nov;128(22):4523-34.
*Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996 Aug 2;273(5275):613-22.
*Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep;18(9):1593-604.
*Long F, Zhang XM, Karp S, Yang Y, McMahon AP. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.Development. 2001 Dec;128(24):5099-108.PBB_Further_reading
citations =
*cite journal | author=Marigo V, Roberts DJ, Lee SM, "et al." |title=Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. |journal=Genomics |volume=28 |issue= 1 |pages= 44–51 |year= 1995 |pmid= 7590746 |doi=
*cite journal | author=Chang DT, López A, von Kessler DP, "et al." |title=Products, genetic linkage and limb patterning activity of a murine hedgehog gene. |journal=Development |volume=120 |issue= 11 |pages= 3339–53 |year= 1995 |pmid= 7720571 |doi=
*cite journal | author=Porter JA, Young KE, Beachy PA |title=Cholesterol modification of hedgehog signaling proteins in animal development. |journal=Science |volume=274 |issue= 5285 |pages= 255–9 |year= 1996 |pmid= 8824192 |doi=
*cite journal | author=Leek JP, Moynihan TP, Anwar R, "et al." |title=Assignment of Indian hedgehog (IHH) to human chromosome bands 2q33-->q35 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 187–8 |year= 1997 |pmid= 9186520 |doi=
*cite journal | author=Pepinsky RB, Zeng C, Wen D, "et al." |title=Identification of a palmitic acid-modified form of human Sonic hedgehog. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 14037–45 |year= 1998 |pmid= 9593755 |doi=
*cite journal | author=Carpenter D, Stone DM, Brush J, "et al." |title=Characterization of two patched receptors for the vertebrate hedgehog protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13630–4 |year= 1998 |pmid= 9811851 |doi=
*cite journal | author=Chuang PT, McMahon AP |title=Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. |journal=Nature |volume=397 |issue= 6720 |pages= 617–21 |year= 1999 |pmid= 10050855 |doi= 10.1038/17611
*cite journal | author=Ito H, Akiyama H, Shigeno C, "et al." |title=Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 2 |pages= 443–51 |year= 1999 |pmid= 10462495 |doi= 10.1006/bbrc.1999.1197
*cite journal | author=Bak M, Hansen C, Friis Henriksen K, Tommerup N |title=The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 300–3 |year= 2001 |pmid= 11435703 |doi=
*cite journal | author=Gao B, Guo J, She C, "et al." |title=Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. |journal=Nat. Genet. |volume=28 |issue= 4 |pages= 386–8 |year= 2001 |pmid= 11455389 |doi= 10.1038/ng577
*cite journal | author=Gritli-Linde A, Lewis P, McMahon AP, Linde A |title=The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. |journal=Dev. Biol. |volume=236 |issue= 2 |pages= 364–86 |year= 2001 |pmid= 11476578 |doi= 10.1006/dbio.2001.0336
*cite journal | author=Kindblom JM, Nilsson O, Hurme T, "et al." |title=Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. |journal=J. Endocrinol. |volume=174 |issue= 2 |pages= R1–6 |year= 2002 |pmid= 12176676 |doi=
*cite journal | author=Cormier S, Delezoide AL, Benoist-Lasselin C, "et al." |title=Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations. |journal=Am. J. Pathol. |volume=161 |issue= 4 |pages= 1325–35 |year= 2002 |pmid= 12368206 |doi=
*cite journal | author=McCready ME, Sweeney E, Fryer AE, "et al." |title=A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved. |journal=Hum. Genet. |volume=111 |issue= 4-5 |pages= 368–75 |year= 2002 |pmid= 12384778 |doi= 10.1007/s00439-002-0815-2
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kirkpatrick TJ, Au KS, Mastrobattista JM, "et al." |title=Identification of a mutation in the Indian Hedgehog (IHH) gene causing brachydactyly type A1 and evidence for a third locus. |journal=J. Med. Genet. |volume=40 |issue= 1 |pages= 42–4 |year= 2003 |pmid= 12525541 |doi=
*cite journal | author=Hellemans J, Coucke PJ, Giedion A, "et al." |title=Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 1040–6 |year= 2003 |pmid= 12632327 |doi=
*cite journal | author=Niemann C, Unden AB, Lyle S, "et al." |title=Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 Suppl 1 |issue= |pages= 11873–80 |year= 2003 |pmid= 12917489 |doi= 10.1073/pnas.1834202100
*cite journal | author=Berman DM, Karhadkar SS, Maitra A, "et al." |title=Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. |journal=Nature |volume=425 |issue= 6960 |pages= 846–51 |year= 2003 |pmid= 14520411 |doi= 10.1038/nature01972
*cite journal | author=Garcia-Barceló MM, Lee WS, Sham MH, "et al." |title=Is there a role for the IHH gene in Hirschsprung's disease? |journal=Neurogastroenterol. Motil. |volume=15 |issue= 6 |pages= 663–8 |year= 2004 |pmid= 14651602 |doi=

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