- IHH
Indian hedgehog homolog (Drosophila), also known as IHH, is a human
gene .cite web | title = Entrez Gene: IHH Indian hedgehog homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3549| accessdate = ] The Indian Hedgehog protein is one of threeprotein s in themammalian hedgehog family, the others beingdesert hedgehog (DHH) andSonic hedgehog (SHH). It is involved inChondrocyte differentiation, proliferation and maturation especially duringEndochondral ossification . It regulates it's effects by feedback control ofparathyroid hormone-related peptide (PTHrP ).PBB_Summary
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summary_text =References
Further reading
* St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999 Aug 15;13(16):2072-86. Erratum in: Genes Dev 1999 Oct 1;13(19):2617.
* Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development. 2000 Feb;127(3):543-8.
*Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development. 2001 Nov;128(22):4523-34.
*Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996 Aug 2;273(5275):613-22.
*Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep;18(9):1593-604.
*Long F, Zhang XM, Karp S, Yang Y, McMahon AP. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.Development. 2001 Dec;128(24):5099-108.PBB_Further_reading
citations =
*cite journal | author=Marigo V, Roberts DJ, Lee SM, "et al." |title=Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. |journal=Genomics |volume=28 |issue= 1 |pages= 44–51 |year= 1995 |pmid= 7590746 |doi=
*cite journal | author=Chang DT, López A, von Kessler DP, "et al." |title=Products, genetic linkage and limb patterning activity of a murine hedgehog gene. |journal=Development |volume=120 |issue= 11 |pages= 3339–53 |year= 1995 |pmid= 7720571 |doi=
*cite journal | author=Porter JA, Young KE, Beachy PA |title=Cholesterol modification of hedgehog signaling proteins in animal development. |journal=Science |volume=274 |issue= 5285 |pages= 255–9 |year= 1996 |pmid= 8824192 |doi=
*cite journal | author=Leek JP, Moynihan TP, Anwar R, "et al." |title=Assignment of Indian hedgehog (IHH) to human chromosome bands 2q33-->q35 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 187–8 |year= 1997 |pmid= 9186520 |doi=
*cite journal | author=Pepinsky RB, Zeng C, Wen D, "et al." |title=Identification of a palmitic acid-modified form of human Sonic hedgehog. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 14037–45 |year= 1998 |pmid= 9593755 |doi=
*cite journal | author=Carpenter D, Stone DM, Brush J, "et al." |title=Characterization of two patched receptors for the vertebrate hedgehog protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13630–4 |year= 1998 |pmid= 9811851 |doi=
*cite journal | author=Chuang PT, McMahon AP |title=Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. |journal=Nature |volume=397 |issue= 6720 |pages= 617–21 |year= 1999 |pmid= 10050855 |doi= 10.1038/17611
*cite journal | author=Ito H, Akiyama H, Shigeno C, "et al." |title=Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 2 |pages= 443–51 |year= 1999 |pmid= 10462495 |doi= 10.1006/bbrc.1999.1197
*cite journal | author=Bak M, Hansen C, Friis Henriksen K, Tommerup N |title=The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 300–3 |year= 2001 |pmid= 11435703 |doi=
*cite journal | author=Gao B, Guo J, She C, "et al." |title=Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. |journal=Nat. Genet. |volume=28 |issue= 4 |pages= 386–8 |year= 2001 |pmid= 11455389 |doi= 10.1038/ng577
*cite journal | author=Gritli-Linde A, Lewis P, McMahon AP, Linde A |title=The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. |journal=Dev. Biol. |volume=236 |issue= 2 |pages= 364–86 |year= 2001 |pmid= 11476578 |doi= 10.1006/dbio.2001.0336
*cite journal | author=Kindblom JM, Nilsson O, Hurme T, "et al." |title=Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. |journal=J. Endocrinol. |volume=174 |issue= 2 |pages= R1–6 |year= 2002 |pmid= 12176676 |doi=
*cite journal | author=Cormier S, Delezoide AL, Benoist-Lasselin C, "et al." |title=Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations. |journal=Am. J. Pathol. |volume=161 |issue= 4 |pages= 1325–35 |year= 2002 |pmid= 12368206 |doi=
*cite journal | author=McCready ME, Sweeney E, Fryer AE, "et al." |title=A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved. |journal=Hum. Genet. |volume=111 |issue= 4-5 |pages= 368–75 |year= 2002 |pmid= 12384778 |doi= 10.1007/s00439-002-0815-2
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kirkpatrick TJ, Au KS, Mastrobattista JM, "et al." |title=Identification of a mutation in the Indian Hedgehog (IHH) gene causing brachydactyly type A1 and evidence for a third locus. |journal=J. Med. Genet. |volume=40 |issue= 1 |pages= 42–4 |year= 2003 |pmid= 12525541 |doi=
*cite journal | author=Hellemans J, Coucke PJ, Giedion A, "et al." |title=Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 1040–6 |year= 2003 |pmid= 12632327 |doi=
*cite journal | author=Niemann C, Unden AB, Lyle S, "et al." |title=Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 Suppl 1 |issue= |pages= 11873–80 |year= 2003 |pmid= 12917489 |doi= 10.1073/pnas.1834202100
*cite journal | author=Berman DM, Karhadkar SS, Maitra A, "et al." |title=Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. |journal=Nature |volume=425 |issue= 6960 |pages= 846–51 |year= 2003 |pmid= 14520411 |doi= 10.1038/nature01972
*cite journal | author=Garcia-Barceló MM, Lee WS, Sham MH, "et al." |title=Is there a role for the IHH gene in Hirschsprung's disease? |journal=Neurogastroenterol. Motil. |volume=15 |issue= 6 |pages= 663–8 |year= 2004 |pmid= 14651602 |doi=PBB_Controls
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