KCNA3

Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K_v1.3, is a human gene.cite web | title = Entrez Gene: KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3738| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.cite web | title = Entrez Gene: KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3738| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Attali B, Romey G, Honoré E, "et al." |title=Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8650–7 |year= 1992 |pmid= 1373731 |doi=
*cite journal | author=Cai YC, Osborne PB, North RA, "et al." |title=Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. |journal=DNA Cell Biol. |volume=11 |issue= 2 |pages= 163–72 |year= 1992 |pmid= 1547020 |doi=
*cite journal | author=Philipson LH, Hice RE, Schaefer K, "et al." |title=Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 1 |pages= 53–7 |year= 1991 |pmid= 1986382 |doi=
*cite journal | author=Grissmer S, Dethlefs B, Wasmuth JJ, "et al." |title=Expression and chromosomal localization of a lymphocyte K+ channel gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9411–5 |year= 1991 |pmid= 2251283 |doi=
*cite journal | author=Folander K, Douglass J, Swanson R |title=Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. |journal=Genomics |volume=23 |issue= 1 |pages= 295–6 |year= 1995 |pmid= 7829094 |doi= 10.1006/geno.1994.1500
*cite journal | author=Bock J, Szabó I, Jekle A, Gulbins E |title=Actinomycin D-induced apoptosis involves the potassium channel Kv1.3. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 2 |pages= 526–31 |year= 2002 |pmid= 12150982 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Panyi G, Bagdány M, Bodnár A, "et al." |title=Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2592–7 |year= 2003 |pmid= 12604782 |doi= 10.1073/pnas.0438057100
*cite journal | author=Hajdú P, Varga Z, Pieri C, "et al." |title=Cholesterol modifies the gating of Kv1.3 in human T lymphocytes. |journal=Pflugers Arch. |volume=445 |issue= 6 |pages= 674–82 |year= 2003 |pmid= 12632187 |doi= 10.1007/s00424-002-0974-y
*cite journal | author=Storey NM, Gómez-Angelats M, Bortner CD, "et al." |title=Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33319–26 |year= 2003 |pmid= 12807917 |doi= 10.1074/jbc.M300443200
*cite journal | author=Preussat K, Beetz C, Schrey M, "et al." |title=Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. |journal=Neurosci. Lett. |volume=346 |issue= 1-2 |pages= 33–6 |year= 2003 |pmid= 12850541 |doi=
*cite journal | author=Mackenzie AB, Chirakkal H, North RA |title=Kv1.3 potassium channels in human alveolar macrophages. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 4 |pages= L862–8 |year= 2003 |pmid= 12909584 |doi= 10.1152/ajplung.00095.2003
*cite journal | author=Grunnet M, Rasmussen HB, Hay-Schmidt A, "et al." |title=KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. |journal=Biophys. J. |volume=85 |issue= 3 |pages= 1525–37 |year= 2004 |pmid= 12944270 |doi=
*cite journal | author=Panyi G, Vámosi G, Bacsó Z, "et al." |title=Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 5 |pages= 1285–90 |year= 2004 |pmid= 14745040 |doi= 10.1073/pnas.0307421100
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Szabò I, Bock J, Jekle A, "et al." |title=A novel potassium channel in lymphocyte mitochondria. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12790–8 |year= 2005 |pmid= 15632141 |doi= 10.1074/jbc.M413548200
*cite journal | author=Rus H, Pardo CA, Hu L, "et al." |title=The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 31 |pages= 11094–9 |year= 2005 |pmid= 16043714 |doi= 10.1073/pnas.0501770102
*cite journal | author=Mullen KM, Rozycka M, Rus H, "et al." |title=Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system. |journal=Ann. Neurol. |volume=60 |issue= 1 |pages= 118–27 |year= 2006 |pmid= 16729292 |doi= 10.1002/ana.20884

External links

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