KCNE4

Potassium voltage-gated channel, Isk-related family, member 4, also known as KCNE4, is a human gene.cite web | title = Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23704| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.cite web | title = Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23704| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Abbott GW, Sesti F, Splawski I, "et al." |title=MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. |journal=Cell |volume=97 |issue= 2 |pages= 175–87 |year= 1999 |pmid= 10219239 |doi=
*cite journal | author=Grunnet M, Jespersen T, Rasmussen HB, "et al." |title=KCNE4 is an inhibitory subunit to the KCNQ1 channel. |journal=J. Physiol. (Lond.) |volume=542 |issue= Pt 1 |pages= 119–30 |year= 2003 |pmid= 12096056 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Teng S, Ma L, Zhen Y, "et al." |title=Novel gene hKCNE4 slows the activation of the KCNQ1 channel. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 808–13 |year= 2003 |pmid= 12670483 |doi=
*cite journal | author=Grunnet M, Rasmussen HB, Hay-Schmidt A, "et al." |title=KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. |journal=Biophys. J. |volume=85 |issue= 3 |pages= 1525–37 |year= 2004 |pmid= 12944270 |doi=
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Grunnet M, Olesen SP, Klaerke DA, Jespersen T |title=hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 4 |pages= 1146–53 |year= 2005 |pmid= 15707997 |doi= 10.1016/j.bbrc.2005.01.071
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Lundquist AL, Turner CL, Ballester LY, George AL |title=Expression and transcriptional control of human KCNE genes. |journal=Genomics |volume=87 |issue= 1 |pages= 119–28 |year= 2006 |pmid= 16303284 |doi= 10.1016/j.ygeno.2005.09.004
*cite journal | author=Zeng Z, Tan C, Teng S, "et al." |title=The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population. |journal=Cardiology |volume=108 |issue= 2 |pages= 97–103 |year= 2007 |pmid= 17016049 |doi= 10.1159/000095943

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes