KCNK4

Potassium channel, subfamily K, member 4, also known as KCNK4, is a human gene.cite web | title = Entrez Gene: KCNK4 potassium channel, subfamily K, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50801| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.cite web | title = Entrez Gene: KCNK4 potassium channel, subfamily K, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50801| accessdate = ]

ee also

* Tandem pore domain potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175–84 |year= 2001 |pmid= 11256078 |doi=
*cite journal | author=Goldstein SA, Bayliss DA, Kim D, "et al." |title=International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 527–40 |year= 2006 |pmid= 16382106 |doi= 10.1124/pr.57.4.12
*cite journal | author=Lesage F, Maingret F, Lazdunski M |title=Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. |journal=FEBS Lett. |volume=471 |issue= 2-3 |pages= 137–40 |year= 2000 |pmid= 10767409 |doi=
*cite journal | author=Chapman CG, Meadows HJ, Godden RJ, "et al." |title=Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. |journal=Brain Res. Mol. Brain Res. |volume=82 |issue= 1-2 |pages= 74–83 |year= 2001 |pmid= 11042359 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Meadows HJ, Chapman CG, Duckworth DM, "et al." |title=The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. |journal=Brain Res. |volume=892 |issue= 1 |pages= 94–101 |year= 2001 |pmid= 11172753 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Ozaita A, Vega-Saenz de Miera E |title=Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. |journal=Brain Res. Mol. Brain Res. |volume=102 |issue= 1-2 |pages= 18–27 |year= 2003 |pmid= 12191490 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Harinath S, Sikdar SK |title=Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. |journal=Neuropharmacology |volume=46 |issue= 5 |pages= 750–60 |year= 2004 |pmid= 14996553 |doi= 10.1016/j.neuropharm.2003.11.023
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139

External links

*

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