CACNB1

Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene.cite web | title = Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=782| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.cite web | title = Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=782| accessdate = ]

ee also

* Voltage-dependent calcium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Williams ME, Feldman DH, McCue AF, "et al." |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71–84 |year= 1992 |pmid= 1309651 |doi=
*cite journal | author=Perez-Reyes E, Castellano A, Kim HS, "et al." |title=Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1792–7 |year= 1992 |pmid= 1370480 |doi=
*cite journal | author=Powers PA, Liu S, Hogan K, Gregg RG |title=Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 22967–72 |year= 1992 |pmid= 1385409 |doi=
*cite journal | author=Pragnell M, Sakamoto J, Jay SD, Campbell KP |title=Cloning and tissue-specific expression of the brain calcium channel beta-subunit. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 253–8 |year= 1991 |pmid= 1657644 |doi=
*cite journal | author=Collin T, Wang JJ, Nargeot J, Schwartz A |title=Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. |journal=Circ. Res. |volume=72 |issue= 6 |pages= 1337–44 |year= 1993 |pmid= 7916667 |doi=
*cite journal | author=Gregg RG, Powers PA, Hogan K |title=Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping. |journal=Genomics |volume=15 |issue= 1 |pages= 185–7 |year= 1993 |pmid= 8381767 |doi= 10.1006/geno.1993.1029
*cite journal | author=Iles DE, Segers B, Sengers RC, "et al." |title=Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 863–8 |year= 1993 |pmid= 8395940 |doi=
*cite journal | author=Fukuda K, Kaneko S, Yada N, "et al." |title=Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. |journal=Neurosci. Lett. |volume=217 |issue= 1 |pages= 13–6 |year= 1997 |pmid= 8905728 |doi=
*cite journal | author=Gregg RG, Messing A, Strube C, "et al." |title=Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13961–6 |year= 1997 |pmid= 8943043 |doi=
*cite journal | author=Brice NL, Dolphin AC |title=Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line. |journal=J. Physiol. (Lond.) |volume=515 ( Pt 3) |issue= |pages= 685–94 |year= 1999 |pmid= 10066897 |doi=
*cite journal | author=Lie AA, Blümcke I, Volsen SG, "et al." |title=Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. |journal=Neuroscience |volume=93 |issue= 2 |pages= 449–56 |year= 1999 |pmid= 10465427 |doi=
*cite journal | author=Hogan K, Greg RG, Powers PA |title=Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. |journal=Neurosci. Lett. |volume=277 |issue= 2 |pages= 111–4 |year= 2000 |pmid= 10624822 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Finlin BS, Crump SM, Satin J, Andres DA |title=Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 14469–74 |year= 2004 |pmid= 14623965 |doi= 10.1073/pnas.2437756100
*cite journal | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, "et al." |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339–46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528
*cite journal | author=Foell JD, Balijepalli RC, Delisle BP, "et al." |title=Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. |journal=Physiol. Genomics |volume=17 |issue= 2 |pages= 183–200 |year= 2004 |pmid= 14762176 |doi= 10.1152/physiolgenomics.00207.2003
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

External links

*

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