Cyclic nucleotide-gated channel alpha 2

Cyclic nucleotide gated channel alpha 2
Identifiers
Symbols	CNGA2; CNCA; CNCA1; CNG2; FLJ46312; OCNC1; OCNCALPHA; OCNCa
External IDs	OMIM: 300338 MGI: 108040 HomoloGene: 32022 GeneCards: CNGA2 Gene
Gene Ontology Molecular function • nucleotide binding • ion channel activity • intracellular cAMP activated cation channel activity • cAMP binding Cellular component • membrane • integral to membrane • intracellular cyclic nucleotide activated cation channel complex Biological process • ion transport • sensory perception of smell • response to stimulus • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1260	12789
Ensembl	ENSG00000183862	ENSMUSG00000005864
UniProt	Q16280	Q80XH6
RefSeq (mRNA)	NM_005140	NM_007724.2
RefSeq (protein)	NP_005131	NP_031750.2
Location (UCSC)	Chr X: 150.91 – 150.91 Mb	Chr X: 69.24 – 69.26 Mb
PubMed search	[1]	[2]

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.^[1]

See also

• Cyclic nucleotide-gated ion channel

References

1. ^ "Entrez Gene: CNGA2 cyclic nucleotide gated channel alpha 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1260. 

Further reading

• Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels.". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507. 
• Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. 
• Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.". Neuropharmacology 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. 
• Finn JT, Krautwurst D, Schroeder JE, et al. (1998). "Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.". Biophys. J. 74 (3): 1333–45. doi:10.1016/S0006-3495(98)77846-4. PMC 1299480. PMID 9512030. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1299480. 
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons.". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22553. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Yoo D, Flagg TP, Olsen O, et al. (2004). "Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions.". J. Biol. Chem. 279 (8): 6863–73. doi:10.1074/jbc.M311599200. PMID 14604981. 
• Cheng KT, Chan FL, Huang Y, et al. (2004). "Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.". Histochem. Cell Biol. 120 (6): 475–81. doi:10.1007/s00418-003-0596-2. PMID 14618336. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Qu W, Moorhouse AJ, Chandra M, et al. (2006). "A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.". J. Gen. Physiol. 127 (4): 375–89. doi:10.1085/jgp.200509378. PMC 2151509. PMID 16533895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2151509. 

External links

• MeSH CNGA2+protein,+human

Na+: Sodium channel
Constitutively active Epithelial sodium channel (α, β, γ, δ) Proton gated Amiloride-sensitive cation channel (1, 2, 3, 4) Voltage-gated Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Navβ (1, 2, 3, 4)

K+: Potassium channel
Voltage-gated Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) Kvβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene Calcium-activated BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · KCa (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1) Inward-rectifier KATP · Kir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/Kir (3.1, 3.2, 3.3, 3.4) · Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other
Cl-: Chloride channel ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B) H+: Voltage-gated HVCN1 M+: TRP cation channel TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6) Cyclic nucleotide-gated (FC) α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4) Porin Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family Gap junction Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4)) Innexin General Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr