Trimebutine

Trimebutine

Systematic (IUPAC) name
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39133-31-8
ATC code	A03AA05
PubChem	CID 5573
UNII	QZ1OJ92E5R Y
Chemical data
Formula	C22H29NO5
Mol. mass	387.47 g/mol
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Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.^[1] The maleic acid salt of trimebutine is marketed under the trademark of Debridat, Recutin, Polybutin,^[2] or Modulon for treatment of irritable bowel syndrome and other gastrointestinal disorders. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine,^[3] which comes from removal of one of the methyl groups attached to nitrogen. Both Trimebutine and its metabolite are commercially available.

References

1. ^ Kaneto H, Takahashi M, Watanabe J. The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. Journal of Pharmacobiodynamics. 1990 Jul;13(7):448-53. PMID 1963196
2. ^ Ok Hwa Jhee, Yun Sik Lee, Leslie M. Shaw, Yong Cheol Jeon, Min Ho Lee, Seung Hoon Lee and Ju Seop Kang The Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC–MS/MS method. Clinica Chimica Acta. 2007 Jan;375(1-2):69-75. PMID 16854404
3. ^ F.J. Roman, S. Lanet, J. Hamon, G. Brunelle, A. Maurin, P. Champeroux, S. Richard, N. Alessandri, and M. Gola Pharmacological Properties of Trimebutine and N-Monodesmethyltrimebutine. The Journal of Pharmacology and Experimental Therapeutics 1999;289:1391–1397. PMID 10336531

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.v · Categories: Benzoates Opioids Phenol ethers Amines Mu-opioid agonists Gastrointestinal system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Rociverine The Party's Over (Murphy's Law album) Look at other dictionaries: Trimébutine — Général Nom IUPAC 3,4,5 triméthoxybenzoate de (R,S) 2 (diméthylamino) 2 phénylbutyle No CAS …   Wikipédia en Français Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia Drug metabolism — is the biochemical modification of pharmaceutical substances by living organisms, usually through specialized enzymatic systems. This is a form of xenobiotic metabolism. Drug metabolism often converts lipophilic chemical compounds into more… …   Wikipedia Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia Opiate — For other uses see Opiate (disambiguation), or for the class of drugs see Opioid. Harvesting the poppy pod. In medicine, the term opiate describes any of the narcotic opioid alkaloids found as natural products in the opium poppy plant …   Wikipedia Phencyclidine — Systematic (IUPAC) name …   Wikipedia Atropine — Systematic (IUPAC) name …   Wikipedia Hyoscyamine — Systematic (IUPAC) name (8 methyl 8 az …   Wikipedia Loperamide — Imodium redirects here. For the song by Nirvana, see Breed (song). Loperamide Systematic (IUPAC) name …   Wikipedia Metoclopramide — Systematic (IUPAC) name 4 amino 5 chloro N (2 (di …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”