- Naloxonazine
-
Naloxonazine 
Other namesNIH 10894; NSC 612113, Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochlorideIdentifiers CAS number 82824-01-9 
PubChem 9576413 IUPHAR ligand 1677 Jmol-3D images Image 1 - C=CCN1[C@H]2[C@]3([C@]4(C5=C(C2)C=CC(=C5O[C@H]4/C(=N/N=C\6/[C@@H]7OC8=C(C=CC9=C8[C@]72[C@]([C@@H](C9)N(CC2)CC=C)(CC6)O)O)/CC3)O)CC1)O
Properties Molecular formula C38H42N4O6 Molar mass 650.76 g mol−1 
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references Naloxonazine is a potent irreversible mu opioid antagonist.[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.[2]
See also
- Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ) a similarly structured opioid also having two complete & mirrored morphinan carbon skeletons but which is a full agonist instead.[3]
References
- ^ Naloxonazine dihydrochloride
- ^ Hahn, E. F.; Pasternak, G. W. (1982-09). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences 31 (12-13): 1385–1388. doi:10.1016/0024-3205(82)90387-3. PMID 6292633. http://www.sciencedirect.com/science/article/pii/0024320582903873. Retrieved 2011-10-18.
- ^ Image of OM-3-MNZ
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