Ocfentanil

Ocfentanil

Systematic (IUPAC) name
N-(2-fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	101343-69-5 Y
ATC code	None
PubChem	CID 60575
UNII	MX52WBC8EV Y
Synonyms	Ocfentanyl, A-3217
Chemical data
Formula	C22H27FN2O2
Mol. mass	370.460 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

Ocfentanil (INN) is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1990s^[1]. It is similar to fentanyl in effects, producing strong analgesia and sedation, but is slightly more potent, with 3μg/kg of ocfentanil being equivalent to 5μg/kg of fentanyl.^[2]

Side effects of fentanyl analogues are similar to those of fentanyl, and include itching, nausea and potentially serious respiratory depression which can be life-threatening.

References

1. ^ US Patent application 2002/176888 A1
2. ^ Fletcher JE, Sebel PS, Murphy MR, Mick SA, Fein S. Comparison of ocfentanil and fentanyl as supplements to general anesthesia. Anesthesia and Analgesia. 1991 Nov;73(5):622-6. PMID 1952145

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