Pethidine Intermediate A

drugbox
IUPAC_name = 1-methyl-4-phenylpiperidine-4-carbonitrile

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CAS_number = 3627-62-1
synonyms = Pethidine Intermediate A
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PubChem = 62513
DrugBank =
C = 13 | H = 16 | N = 2
molecular_weight = 200.28 g/mol
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legal_US = Schedule I
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routes_of_administration = N/A

Pethidine Intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active, [Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. "Journal of Medicinal Chemistry". 2005; 48:1336-1343.] so Pethidine Intermediate A might also show opioid effects.

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