Ethoheptazine

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IUPAC_name = Ethyl 1-methyl-4-phenylazepane-4-carboxylate
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CAS_number = 77-15-6
synonyms = Ethoheptazine, Zactane, Equagesic
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PubChem = 6469
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C = 16 | H = 23 | N = 1 | O = 2
molecular_weight = 261.36 g/mol
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legal_US = Schedule V
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Ethoheptazine (Zactane, Equagesic) is an opioid analgesic from the phenazepine family. It was invented in the 1950s [Batterman RC, Golbey M, Grossman AJ, Leifer P. Analgesic effectiveness of orally administered ethoheptazine in man. "American Journal of Medical Sciences". 1957 Oct;234(4):413-9.] and is related to other drugs such as proheptazine. [Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). "Journal of Medicinal Chemistry". 1964 Jan;7:57-60.]

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea. [Cinelli P, Zucchini M. Current pharmaco-therapeutic possibilities in the treatment of pain. Experiments with ethoeptazine. (Italian). "Minerva Medica". 1962 Mar 3;53:637-42.] It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present. [Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. "Current Therapeutic Research, Clinical and Experimental". 1974 Sep;16(9):928-36.]

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