Semorphone

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IUPAC_name = (5α)-4,6-Epoxy-3,14-dihydroxy-17-(2-methoxyethyl)morphinan-6-one

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CAS_number = 88939-40-6
synonyms = Semorphone, Mr 2264
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PubChem = 5491906
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C = 19 | H = 23 | N = 1 | O = 5
molecular_weight = 345.39 g/mol
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Semorphone (Mr 2264) is an opiate analogue that is an N-substituted derivative of oxymorphone.

Semorphone is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression [Behne M, Bremerich D, Heinrich J, Schumacher H, Scherer M. Respiratory effects and tolerability of Mr 2264 Cl. A new opiate partial agonist in comparison with morphine and placebo. "European Journal of Clinical Pharmacology". 1994;46(4):301-4.] which means that these effects stop becoming any stronger after a certain maximum dose.

It is not currently used in medicine, and is not a controlled drug, although it might be considered to be a controlled substance analogue of oxymorphone on the grounds of its related chemical structure in some jurisdictions such as the USA, Canada, Australia and New Zealand.

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