Nortilidine

Nortilidine: Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 38677-94-0

ATC code ?

ChEMBL CHEMBL1614654

Chemical data

Formula H₂₁N O₂

Mol. mass 259.3434 g/mol

SMILES eMolecules & PubChem

InChI

InChI=InChI=1S/C16H21NO2/c1-3-19-15(18)16(13-9-5-4-6-10-13)12-8-7-11-14(16)17-2/h4-7,9-11,14,17H,3,8,12H2,1-2H3/t14-,16+/m1/s1
Key:InChIKey=PDJZPNKVLDWEKI-ZBFHGGJFSA-N

Nortilidine^[1] is the active metabolite of the drug Tilidine. It is formed from Tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine^[2] but virtually all of the activity resides in the (1R,2S) isomer.

^ US Patent 3792080 - Process for Substituted Cyclohexenes & it's Products

^ J Clin Pharmacol. 2002 Nov ;42 (11):1257-61 - Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine

Categories:
Opioids



Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	38677-94-0
ATC code	?
ChEMBL	CHEMBL1614654
Chemical data
Formula	H₂₁N O₂
Mol. mass	259.3434 g/mol
SMILES	eMolecules & PubChem
InChI InChI=InChI=1S/C16H21NO2/c1-3-19-15(18)16(13-9-5-4-6-10-13)12-8-7-11-14(16)17-2/h4-7,9-11,14,17H,3,8,12H2,1-2H3/t14-,16+/m1/s1 Key:InChIKey=PDJZPNKVLDWEKI-ZBFHGGJFSA-N

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