N-Phenethyl-14-ethoxymetopon

N-Phenethyl-14-ethoxymetopon

Systematic (IUPAC) name
(5α)-14-ethoxy- 3-hydroxy- 5-methyl- 17-(2-phenylethyl)- 4,5-epoxymorphinan- 6-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 11049533
Chemical data
Formula	C27H31NO4
Mol. mass	433.538 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

N-Phenethyl-14-ethoxymetopon is a drug which is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.^[1]

N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.^[2]

See also

• 14-Cinnamoyloxycodeinone
• 14-Phenylpropoxymetopon
• 7-PET
• N-Phenethylnormorphine
• Phenomorphan
• RAM-378
• Ro4-1539

References

1. ^ Ananthan, S (2006). "Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics". The AAPS journal 8 (1): E118–25. doi:10.1208/aapsj080114. PMC 2751430. PMID 16584118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2751430. 
2. ^ Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of medicinal chemistry 48 (9): 3372–8. doi:10.1021/jm040894o. PMID 15857143. 

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