- N-Phenethylnordesomorphine
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N-Phenethylnordesomorphine 
Systematic (IUPAC) name 3-hydroxy-4,5α-epoxy-17-(2-phenylethyl)morphinan Clinical data Pregnancy cat. ? Legal status ? Identifiers ATC code ? ChemSpider 26231038 
Chemical data Formula C24H27NO2 Mol. mass 361.477 g/mol SMILES eMolecules & PubChem - InChI=1S/C24H27NO2/c26-20-10-9-17-15-19-18-7-4-8-21-24(18,22(17)23(20)27-21)12-14-25(19)13-11-16-5-2-1-3-6-16/h1-3,5-6,9-10,18-19,21,26H,4,7-8,11-15H2/t18-,19+,21-,24+/m0/s1
Key:JZVQXSYNZPVRTQ-FPRSRYDQSA-N
(what is this?) (verify)N-Phenethylnordesomorphine is an opiate analgesic drug derived from desomorphine by replacing the N-methyl group with β-phenethyl. Since desomorphine is already around eight times more potent than morphine, the additional boost in binding affinity produced by using the larger phenethyl group makes N-phenethylnordesomorphine a highly potent analgesic drug, some 85x more potent than morphine,[1] and a similar strength to the closely related morphinan derivative phenomorphan.
See also
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- N-Phenethyl-14-ethoxymetopon
- N-Phenethylnormorphine
- RAM-378
- Ro4-1539
References
- ^ Casy AF, Parfitt RY. Opioid analgesics, chemistry and receptors. 1986, Plenum Press, New York. pp 37-38. ISBN 0306421305
This analgesic-related article is a stub. You can help Wikipedia by expanding it. - InChI=1S/C24H27NO2/c26-20-10-9-17-15-19-18-7-4-8-21-24(18,22(17)23(20)27-21)12-14-25(19)13-11-16-5-2-1-3-6-16/h1-3,5-6,9-10,18-19,21,26H,4,7-8,11-15H2/t18-,19+,21-,24+/m0/s1
