DADLE

DADLE: DADLE

IUPAC name

(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid

Other names

• [D-Ala², D-Leu⁵]-Enkephalin
• L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine
• N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine
• Tyr-D-Ala-Gly-Phe-D-Leu-OH

Identifiers

CAS number 63631-40-3

PubChem 6917707

Jmol-3D images Image 1

SMILES

N[C@H](C(N[C@H](C)C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2

Properties

Molecular formula C₂₉H₃₉N₅O₇

Molar mass 569.65 g mol⁻¹

Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

DADLE ([D-Ala², D-Leu⁵]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective delta opioid receptor agonist, it also binds to the μ₁ subtype of mu opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.^[1]^[2]

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

References

^ Medical Dictionary Online

^ Online Medical Dictionary, enkephalin, leucine-2-alanine

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Academic Dictionaries and Encyclopedias

DADLE

IUPAC name (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Other names • [D-Ala², D-Leu⁵]-Enkephalin • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH
Identifiers
CAS number	63631-40-3
PubChem	6917707
Jmol-3D images	Image 1
SMILES N[C@H](C(N[C@H](C)C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2
Properties
Molecular formula	C₂₉H₃₉N₅O₇
Molar mass	569.65 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references