Viminol

drugbox
IUPAC_name = 1- [1- [(2-chlorophenyl)methyl] pyrrol-2-yl] -2-(di(butan-2-yl)amino)ethanol

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width = 180
CAS_number = 21363-18-8
synonyms = Viminol, Dividol
ATC_prefix = N02
ATC_suffix = BG05
PubChem = 65697
DrugBank =
C = 21 | H = 31 | Cl = 1 | N = 2 | O = 1
molecular_weight = 362.94 g/mol
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legal_status = Rx-Only
routes_of_administration = Oral

Viminol (marketed under the brandname Dividol) is a drug which is an opioid analgesic. It has an unusual chemical structure that is not similar to other opioids. [Contri AM. Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination. (Italian). "Il Farmaco". 1981 Apr;36(4):215-22.] [Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. "Revista Brasileira de Pesquisas Medicas e Biologicas". 1977 Dec;10(6):361-8.]

Viminol has both antitussive (cough suppressing) and analgesic (pain reducing) effects. It has six different stereoisomers which have varying properties, with the 2-("R") isomer being a μ-opioid full agonist slightly more potent than morphine, while the 2-("S") isomer is an antagonist. [Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. "Pharmacology, Biochemistry and Behaviour". 1984 Jan;20(1):59-62.] Since vimonol is supplied as a racemic mixture of isomers, the overall effect produces a mixed agonist-antagonist profile similar to that of opioids such as pentazocine, although with somewhat less side effects. [Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. "International Journal of Clinical Pharmacology, Therapy and Toxicology". 1986 May;24(5):232-5.]

Viminol has similar effects to other opioids, and produces analgesia, sedation and euphoria.

ide Effects

Side effects are similar to other opioids, and can include:
*Itching
*Nausea
*Sedation
*Respiratory depression - can be potentially life-threatening

However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.

References