Classification and external resources

Micrograph showing chorioamnionitis. The clusters of blue dots are inflammatory cells (neutrophils, eosinophils and lymphocytes). H&E stain.
ICD-10 O41.1, P02.7
ICD-9 658.4, 762.7
eMedicine ped/89
MeSH D002821

Chorioamnionitis is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. It typically results from bacteria ascending into the uterus from the vagina and is most often associated with prolonged labour. Risk of developing chorioamnionitis increases with each vaginal exam during final month of pregnancy and during labor.[3]



The fetal membranes consist of two parts:

  • The outer membrane is the chorion. It is closest to the mother and physically supports the much thinner amnion.
  • The inner membrane is the amnion. It is in direct contact with the amniotic fluid, which surrounds the fetus.


Intermediate magnification micrograph of moderate chorioamnionitis. H&E stain.


Chorioamnionitis is diagnosed clinically in the setting of:[1]



Chorioamnionitis can be diagnosed from a histologic examination of the fetal membranes.

Infiltration of the chorionic plate by neutrophils is diagnostic of (mild) chorioamnionitis. More severe chorioamnionitis involves subamniotic tissue and may have fetal membrane necrosis and/or abscess formation.

Severe chorioamnionitis may be accompanied by vasculitis of the umbilical vessels (due to the fetus' inflammatory cells) and, if very severe, funisitis (inflammation of the umbilical cord's connective tissue).


Treatment consists of:


Chorioamnionitis is a risk factor for periventricular leukomalacia and cerebral palsy.[2]

See also


  1. ^ Elmar Peter Sakala, MD, MA, MPH, FACOG. Professor of GYNOB, Loma Linda University of medicine, California. Codirector of Student Clerkship. Dept of GYNOB
  2. ^ Wu YW, Colford JM (2000). "Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis". JAMA 284 (11): 1417–24. doi:10.1001/jama.284.11.1417. PMID 10989405. 

3. Excess Digital Exams Raise Risk of Chorioamnionitis, Ob.Gyn. News, August 15, 1997

External links

Wikimedia Foundation. 2010.

Поможем решить контрольную работу

Look at other dictionaries:

  • chorioamnionitis — noun Inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection, most often associated with prolonged labour …   Wiktionary

  • chorioamnionitis — Infection involving the chorion, amnion, and amniotic fluid; usually the placental villi and decidua are also involved. * * * cho·rio·am·ni·o·ni·tis .am nē ō nīt əs n inflammation of the fetal membranes * * * cho·rio·am·ni·o·ni·tis (kor …   Medical dictionary

  • Chorioamnionitis — Chorio|amnio|ni̱tis [zu ↑Chorion u. ↑Amnion] w; , ...iti̱den (in fachspr. Fügungen: ...i̱tides): bakterielle Infektion des Chorions und Amnions …   Das Wörterbuch medizinischer Fachausdrücke

  • хориоамнионит — (chorioamnionitis; хорион + амнион + ит) сочетанное воспаление хориона и амниона …   Большой медицинский словарь

  • Хориоамниони́т — (chorioamnionitis: Хорион + Амнион + ит) сочетанное воспаление хориона и амниона …   Медицинская энциклопедия

  • Preterm birth — Classification and external resources Intubated preterm baby in an incubator ICD 10 O …   Wikipedia

  • Premature rupture of membranes — (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor. PROM is prolonged when it occurs more than 18 hours before labor. PROM is preterm (PPROM) when it occurs before 37 weeks… …   Wikipedia

  • Omphalitis — Classification and external resources ICD 10 P38 ICD 9 771.4 DiseasesDB …   Wikipedia

  • Plazentitis — Klassifikation nach ICD 10 O41.1 Infektion der Fruchtblase und der Eihäute Plazentitis …   Deutsch Wikipedia

  • Amniotic band syndrome — Classification and external resources ICD 10 P02.8 ICD 9 762.8 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”