- Functio laesa
Functio laesa is a term used in medicine to refer to a loss of functioncite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/seven/000096919.htm |title=Dorlands Medical Dictionary:cardinal signs] cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?functio+laesa |title=Definition: functio laesa from Online Medical Dictionary |format= |work= |accessdate=] or a disturbance of function.cite journal |author=Rather LJ |title=Disturbance of function (functio laesa): The legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus |journal=Bull N Y Acad Med |volume=47 |issue=3 |pages=303–22 |year=1971 |month=March |pmid=5276838 |pmc=1749862 |doi= |url=]
It was identified as the fifth sign of acute
inflammationby Galen,cite book |author=Porth, Carol |title=Essentials of pahtophysiology: concepts of altered health states |publisher=Lippincott Williams & Wilkins |location=Hagerstown, MD |year=2007 |pages=270 |isbn=0-7817-7087-4 |oclc= |doi= |accessdate=] who added it to the four signs identified by Celsus ( tumor, rubor, calor, and dolor).
The attribution to Galen is not undisputed. Origination of the phrase has also been ascribed to
Thomas Sydenhamcite book |author=Dormandy, Thomas |title=The worst of evils: man's fight against pain |publisher=Yale University Press |location=New Haven, Conn |year=2006 |pages=22 |isbn=0-300-11322-6 |oclc= |doi= |accessdate=] and Rudolf Virchow.cite book |author=David Lowell Strayer; Raphael Rubin |title=Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition |publisher=Lippincott Williams & Wilkins |location=Hagerstown, MD |year=2007 |pages=37 |isbn=0-7817-9516-8 |oclc= |doi= |accessdate=]
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