Hematologic disease

Hematologic disease


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Hematologic diseases are disorders which primarily affect the blood.

Classification of hematologic diseases

*Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
**Sickle-cell disease
*Anemias (lack of red blood cells or hemoglobin)
**Iron deficiency anemia
**Megaloblastic anemia
***Vitamin B12 deficiency
****Pernicious anemia
***Folate deficiency
**Hemolytic anemias (destruction of red blood cells)
***Genetic disorders of RBC membrane
****Hereditary spherocytosis
****Hereditary elliptocytosis
***Genetic disorders of RBC metabolism
****Glucose-6-phosphate dehydrogenase deficiency (G6PD)
****Pyruvate kinase deficiency
***Immune mediated hemolytic anaemia (direct Coombs test is positive)
****Autoimmune hemolytic anemia
*****Warm antibody autoimmune hemolytic anemia
******Systemic lupus erythematosus (SLE)
******Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
*****Cold antibody autoimmune hemolytic anemia
******Idiopathic cold hemagglutinin syndrome
******Infectious mononucleosis
******Paroxysmal cold hemoglobinuria (rare)
****Alloimmune hemolytic anemia
*****Hemolytic disease of the newborn (HDN)
******Rh disease (Rh D)
******ABO hemolytic disease of the newborn
******Anti-Kell hemolytic disease of the newborn
******Rhesus c hemolytic disease of the newborn
******Rhesus E hemolytic disease of the newborn
******Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
****Drug induced immune mediated hemolytic anaemia
*****Penicillin (high dose)
***Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
***Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
***Direct physical damage to RBCs
****Microangiopathic hemolytic anemia
****Secondary to artificial heart valve(s)
**Aplastic anemia
***Fanconi anemia
***Diamond-Blackfan anemia
***Acquired pure red cell aplasia
*Decreased numbers of cells
**Myelodysplastic syndrome
**Neutropenia (decrease in the number of neutrophils)
**Glanzmann's thrombasthenia
**Thrombocytopenia (decrease in the number of platelets)
***Idiopathic thrombocytopenic purpura (ITP)
***Thrombotic thrombocytopenic purpura (TTP)
***Heparin-induced thrombocytopenia (HIT)
*Myeloproliferative disorders (Increased numbers of cells)
**Polycythemia vera (increase in the number of cells in general)
**Leukocytosis (increase in the number of white blood cells)
**Thrombocytosis (increase in the number of platelets)
**Myeloproliferative disorder
*Hematological malignancies
***Hodgkin's disease
***Non-Hodgkin's lymphoma{includes the next eight entries}
***Burkitt's lymphoma
***Anaplastic large cell lymphoma
***Splenic marginal zone lymphoma
***Hepatosplenic T-cell lymphoma
***Angioimmunoblastic T-cell lymphoma (AILT)
***Multiple myeloma
***Waldenström macroglobulinemia
***Acute lymphocytic leukemia (ALL)
***Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
***Acute myelogenous leukemia (AML)
***Chronic myelogenous leukemia (CML)
***T-cell prolymphocytic leukemia (T-PLL)
***B-cell prolymphocytic leukemia (B-PLL)
***Chronic neutrophilic leukemia (CNL)
***Hairy cell leukemia (HCL)
***T-cell large granular lymphocyte leukemia (T-LGL)
***Aggressive NK-cell leukemia
*Coagulopathies (disorders of bleeding and coagulation)
**Recurrent thrombosis
**Disseminated intravascular coagulation
**Disorders of clotting proteins
****Hemophilia A
****Hemophilia B (also known as Christmas disease)
****Hemophilia C
***Von Willebrand disease
***Disseminated intravascular coagulation
***Protein S deficiency
***Antiphospholipid syndrome
**Disorders of platelets
***Glanzmann's thrombasthenia
***Wiskott-Aldrich syndrome
***Gauchers disease
**Monoclonal gammopathy of undetermined significance
*Hematological changes secondary to non-hematological disorders
**Anemia of chronic disease
**Infectious mononucleosis

External links

* http://www.hematologic.niddk.nih.gov/info/index.htm
* [http://www.mpdfoundation.org Myeloproliferative Disorders (MPD) Foundation and Research Alliance]

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