- Panniculitis
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Panniculitis Classification and external resources ICD-10 M79.3 ICD-9 729.3 DiseasesDB 29081 MeSH D015434 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin - panniculus adiposus).[1] Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.
Restated, an inflammatory disorder primarily localized in the subcutaneous fat is termed a "panniculitis," a group of disorders that may be challenging both for the clinician and the dermatopathologist.[2]:487
Contents
Classification
Histological
It can occur in any fatty tissue (cutaneous or visceral) and is often diagnosed on the basis of a deep skin biopsy, and can be further classified by histological characteristics based on the location of the inflammatory cells (within fatty lobules or in the septa which separate them) and on the presence or absence of vasculitis.
There are thus four main histological subtypes:[3]
- lobular panniculitis without vasculitis (acute panniculitis, previously termed Weber-Christian disease,[4] systemic nodular panniculitis)
- lobular panniculitis with vasculitis
- septal panniculitis without vasculitis
- septal panniculitis with vasculitis
Symptomatic
Panniculitis can also be classified based on the presence or absence of systemic symptoms:
- Panniculitis without systemic disease can be a result of trauma or cold;[5]
- Panniculitis with systemic disease can be caused...
- by connective tissue disorders such as lupus erythematosus or scleroderma;
- by lymphoproliferative disease such as lymphoma or histiocytosis;
- by pancreatitis or pancreatic cancer;
- by sarcoidosis with cutaneous involvement (seen in up to 20 percent)
- and by many other causes.
Associated conditions
Lipoatrophy or lipodystrophy (the loss of subcutaneous adipose tissue) can occur in any of these conditions.
See also
- Erythema induratum
- Erythema nodosum
- Panniculus adiposus
- Panniculus carnosus
- Lipodermatosclerosis
- List of cutaneous conditions
References
- ^ "panniculitis" at Dorland's Medical Dictionary
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ "Panniculitis. DermNet NZ". http://dermnetnz.org/dermal-infiltrative/panniculitis.html. Retrieved 2010-05-17.
- ^ "eMedicine - Weber-Christian Disease : Article by Moise L Levy". http://www.emedicine.com/ped/topic2429.htm. Retrieved 2008-03-25.
- ^ "eMedicine - Cold Panniculitis : Article by Geromanta Baleviciene". http://www.emedicine.com/derm/topic781.htm. Retrieved 2008-03-25.
External links
Disorders of subcutaneous fat (M79.3, 729.3) Panniculitis Lobularwithout vasculitis: Cytophagic histiocytic panniculitis · Factitial panniculitis · Gouty panniculitis · Pancreatic panniculitis · Traumatic panniculitis (Cold panniculitis) · needle-shaped clefts (Subcutaneous fat necrosis of the newborn, Sclerema neonatorum, Post-steroid panniculitis) · Lipodermatosclerosis · Weber–Christian disease · Lupus erythematosus panniculitis · Sclerosing lipogranulomawith vasculitis: Nodular vasculitis/Erythema induratumSeptalwithout vasculitis: Alpha-1 antitrypsin deficiency panniculitis · Erythema nodosum (Acute erythema nodosum, Chronic erythema nodosum)with vasculitis: Superficial thrombophlebitisLipodystrophy Acquiredgeneralized: Acquired generalized lipodystrophy
partial: Acquired partial lipodystrophy · Centrifugal abdominal lipodystrophy · HIV-associated lipodystrophy · Lipoatrophia annularis
localized: Localized lipodystrophyCongenitalCongenital generalized lipodystrophy · Familial partial lipodystrophy
Poland's syndromeCategories:- Conditions of the subcutaneous fat
- Soft tissue disorders
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