Epithelioid cell

Epithelioid cell

Epithelioid histiocytes (Epithelioid cells) are activated macrophages resembling epithelial cells:cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/two/000018652.htm |title=Dorlands Medical Dictionary:epithelioid cell |format= |work= |accessdate=] elongated, with finely granular, pale eosinophilic (pink) cytoplasm and central, ovoid nucleus(oval or elongate), which is less dense than that of a lymphocyte. They have indistinct shape contour, often appear to merge into one another and form aggregates.

Clinical significance

The presence of epithelioid histiocytes may characterise some pathologic conditions, mainly granulomatous inflammation, including Orofacial granulomatosis [cite journal |author=Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W |title=Orofacial granulomatosis as the initial presentation of Crohn's disease in an adolescent |journal=Dermatology (Basel) |volume=206 |issue=3 |pages=273–8 |year=2003 |pmid=12673090 |doi=10.1159/000068900] . The excessive proliferation of them on skin causes reticulohistiocytoma and somewhat it is associated with arthritis.

ee also

*Epithelioid
*Granulomatous

References

External links

*


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