Lupus erythematosus

Lupus erythematosus
Classification and external resources
ICD-10	L93 (ILDS L93.010)
ICD-9	695.4

Lupus erythematosus is a category for a collection of diseases with similar underlying problems with immunity (autoimmune disease).^[1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. Four main types of lupus exist — systemic lupus erythematosus, discoid lupus erythematosus, drug-induced lupus erythematosus, and neonatal lupus erythematosus. Of these, systemic lupus erythematosus is the most common and serious form of lupus.

Photosensitivity's relationship to and influence on the systemic manifestations of lupus remain to be defined. Mechanisms for photosensitivity might include: modulation of autoantibody location, cytotoxic effects, apoptosis induction with autoantigens in apoptotic blebs, upregulation of adhesion molecules and cytokines, induction of nitric oxide synthase expression and ultraviolet-generated antigenic DNA. Tumor necrosis factor alpha also seems to play a role in the development of photosensitivity.^[2]

Types

Lupus erythematosus may manifest as a systemic disease or in purely cutaneous forms. Types of lupus erythematosus can be categorized into the following types:^[3][4]

• Acute cutaneous lupus erythematosus
• Subacute cutaneous lupus erythematosus
• Chronic cutaneous lupus erythematosus
  • Discoid lupus erythematosus
    • Childhood discoid lupus erythematosus
    • Generalized discoid lupus erythematosus
    • Localized discoid lupus erythematosus
  • Chilblain lupus erythematosus (Hutchinson)
  • Lupus erythematosus-lichen planus overlap syndrome
  • Lupus erythematosus panniculitis (Lupus erythematosus profundus)
  • Tumid lupus erythematosus
  • Verrucous lupus erythematosus (Hypertrophic lupus erythematosus)
• Complement deficiency syndromes
• Drug-induced lupus erythematosus
• Neonatal lupus erythematosus
• Systemic lupus erythematosus

See also

• List of cutaneous conditions

References

1. ^ Fitzpatrick, Thomas B.; Klauss Wolff; Wolff, Klaus Dieter; Johnson, Richard R.; Suurmond, Dick; Richard Suurmond (2005). Fitzpatrick's color atlas and synopsis of clinical dermatology. New York: McGraw-Hill Medical Pub. Division. ISBN 0-07-144019-4. 
2. ^ Scheinfeld NS, Deleo V. Photosensitivity in lupus erythematosus. Photodermatol Photoimmunol Photomed. 2004;20:272-9. PMID 15379880
3. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Chapter 8. ISBN 0721629210.
4. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 

External Sites

• How Do You Get Lupus?

This cutaneous condition article is a stub. You can help Wikipedia by expanding it.v · Categories: Connective tissue diseases Cutaneous condition stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Chronic diarrhea of infancy Chronic endothelial injury hypothesis Look at other dictionaries: Lupus erythematosus — Lupus érythémateux disséminé Pour les articles homonymes, voir Lupus et LED. Lupus érythémateux disséminé Classification et ressources externes …   Wikipédia en Français Lupus erythematosus — Lupus Lu pus, n. [L., a wolf. See {Wolf}.] 1. (Med.) originally, a cutaneous disease with the appearance of the skin having been gnawed, and occurring under two distinct forms. Now used as a generic term for over ten distinguishable diseases… …   The Collaborative International Dictionary of English lupus erythematosus — lupus er·y·the·ma·to·sus .er ə .thē mə tō səs n a disorder characterized by skin inflammation esp SYSTEMIC LUPUS ERYTHEMATOSUS * * * (LE) a chronic inflammatory disease of connective tissue, affecting the skin and various internal organs… …   Medical dictionary lupus erythematosus — [er΄ə thē΄mə tō′səs, er΄əthem΄ətō′səs] n. [ModL, lit., erythematous lupus] a usually chronic inflammatory disease in which immunological reactions cause abnormalities of blood vessels and connective tissue: the systemic form commonly involves the …   English World dictionary lupus erythematosus — /er euh thee meuh toh seuhs, them euh /, Pathol. any of several autoimmune diseases, esp. systemic lupus erythematosus, characterized by red, scaly skin patches. [1855 60; < NL: erythematous lupus] * * * Either of two inflammatory autoimmune… …   Universalium lupus erythematosus — noun Etymology: New Latin, literally, erythematous lupus Date: 1860 a disorder characterized by skin inflammation; especially systemic lupus erythematosus …   New Collegiate Dictionary lupus erythematosus — Skin disease in which there are red scaly patches, especially over the nose and cheeks. May be a symptom of systemic lupus erythematosus …   Dictionary of molecular biology lupus erythematosus — lu′pus er•y•the•ma•to′sus [[t]ˌɛr əˌθi məˈtoʊ səs, ˌθɛm ə [/t]] n. pat any of several autoimmune diseases, esp. systemic lupus erythematosus, characterized by red, scaly skin patches • Etymology: 1855–60; < NL …   From formal English to slang lupus erythematosus cell — n LE CELL …   Medical dictionary lupus erythematosus profundus — a rare chronic form of cutaneous lupus erythematosus characterized by dermal and subcutaneous inflammatory involvement, with deep, firm nodules, often without surface change. The usual location is on the head, upper arms, chest, buttocks, or… …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”