- Gleich's syndrome
Gleich's syndrome or episodic angioedema with eosinophilia is a rare disease in which the body swells up episodically (
angioedema ), associated with raised antibodies of theIgM type and increased numbers ofeosinophil granulocyte s, a type ofwhite blood cell s, in the blood (eosinophilia ). It was first described in 1984.cite journal |author=Gleich GJ, Schroeter AL, Marcoux JP, Sachs MI, O'Connell EJ, Kohler PF |title=Episodic angioedema associated with eosinophilia |journal=N. Engl. J. Med. |volume=310 |issue=25 |pages=1621–6 |year=1984 |pmid=6727934 |doi=]Its cause is unknown, but it is unrelated to
capillary leak syndrome (which may cause similar swelling episodes) andeosinophilia-myalgia syndrome (which features eosinophilia but alternative symptoms). Moreover, it is not a form ofhypereosinophilic syndrome as there is no evidence that it leads to organ damage. Some studies have shown that edema attacks are associated with degranulation (release of enzymes and mediators from eosinophils), and others have demonstrated antibodies againstendothelium (cells lining blood vessels) in the condition.cite journal |author=Emonet S, Kaya G, Hauser C |title=Gleich's syndrome |journal=Ann Dermatol Venereol |volume=127 |issue=6-7 |pages=616–8 |year=2000 |pmid=10930860 |url=http://www.masson.fr/masson/portal/bookmark?Global=1&Path=REVUE/ADE/2000/127/6_7/ARTICLE11105965522.xml|doi=]Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment.
References
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