Pyoderma gangrenosum

Pyoderma gangrenosum

Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.

The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.Jackson JM and Callen JP. 2006. [http://www.emedicine.com/DERM/topic367.htm Emedicine: Pyoderma Gangrenosum.] Retrieved on January 23, 2007.]

Types

There are two main types of pyoderma gangrenosum:
* the normal ulcerative form, which occurs in the legs
* an 'atypical' form that is more superficial and occurs in the hands and other parts of the body

Other variations arecite journal |author=Brooklyn T, Dunnill G, Probert C |title=Diagnosis and treatment of pyoderma gangrenosum |journal=BMJ |volume=333 |issue=7560 |pages=181–4 |year=2006 |pmid=16858047 |doi=10.1136/bmj.333.7560.181] :
* Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
* Bullous pyoderma gangrenosum
* Pustular pyoderma gangrenosumcite journal |author=Shankar S, Sterling JC, Rytina E |title=Pustular pyoderma gangrenosum |journal=Clin. Exp. Dermatol. |volume=28 |issue=6 |pages=600–3 |year=2003 |pmid=14616824 |doi=10.1046/j.1365-2230.2003.01418.x ]
* Vegetative pyoderma gangrenosumcite journal |author=Langan SM, Powell FC |title=Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature |journal=Int. J. Dermatol. |volume=44 |issue=8 |pages=623–9 |year=2005 |pmid=16101860 |doi=10.1111/j.1365-4632.2005.02591.x]

Causes

Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function. For instance, ulcerative colitis, Crohn's disease, rheumatoid arthritis, myeloma sufferers have the condition.

Associations

The common conditions associated with pyoderma gangrenosum are:
*Inflammatory bowel disease:
**Chronic ulcerative colitis
**Crohn's disease
*Arthritides:
**Rheumatoid arthritis
**Seronegative symmetrical polyarthritis
*Haematological disease:
**Myelocytic leukaemia
**Hairy cell leukaemia
**Myelofibrosis
**Myeloid metaplasia
**Monoclonal gammopathy (IgA) [ [http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no Maintenance on GPnotebook site ] ]

Treatment

A number of treatment options exist.cite journal |author=Reichrath J, Bens G, Bonowitz A, Tilgen W |title=Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients |journal=J. Am. Acad. Dermatol. |volume=53 |issue=2 |pages=273–83 |year=2005 |pmid=16021123 |doi=10.1016/j.jaad.2004.10.006]

References

External links

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