Pyoderma gangrenosum

Pyoderma gangrenosum

Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.

The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.Jackson JM and Callen JP. 2006. [http://www.emedicine.com/DERM/topic367.htm Emedicine: Pyoderma Gangrenosum.] Retrieved on January 23, 2007.]

Types

There are two main types of pyoderma gangrenosum:
* the normal ulcerative form, which occurs in the legs
* an 'atypical' form that is more superficial and occurs in the hands and other parts of the body

Other variations arecite journal |author=Brooklyn T, Dunnill G, Probert C |title=Diagnosis and treatment of pyoderma gangrenosum |journal=BMJ |volume=333 |issue=7560 |pages=181–4 |year=2006 |pmid=16858047 |doi=10.1136/bmj.333.7560.181] :
* Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
* Bullous pyoderma gangrenosum
* Pustular pyoderma gangrenosumcite journal |author=Shankar S, Sterling JC, Rytina E |title=Pustular pyoderma gangrenosum |journal=Clin. Exp. Dermatol. |volume=28 |issue=6 |pages=600–3 |year=2003 |pmid=14616824 |doi=10.1046/j.1365-2230.2003.01418.x ]
* Vegetative pyoderma gangrenosumcite journal |author=Langan SM, Powell FC |title=Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature |journal=Int. J. Dermatol. |volume=44 |issue=8 |pages=623–9 |year=2005 |pmid=16101860 |doi=10.1111/j.1365-4632.2005.02591.x]

Causes

Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function. For instance, ulcerative colitis, Crohn's disease, rheumatoid arthritis, myeloma sufferers have the condition.

Associations

The common conditions associated with pyoderma gangrenosum are:
*Inflammatory bowel disease:
**Chronic ulcerative colitis
**Crohn's disease
*Arthritides:
**Rheumatoid arthritis
**Seronegative symmetrical polyarthritis
*Haematological disease:
**Myelocytic leukaemia
**Hairy cell leukaemia
**Myelofibrosis
**Myeloid metaplasia
**Monoclonal gammopathy (IgA) [ [http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no Maintenance on GPnotebook site ] ]

Treatment

A number of treatment options exist.cite journal |author=Reichrath J, Bens G, Bonowitz A, Tilgen W |title=Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients |journal=J. Am. Acad. Dermatol. |volume=53 |issue=2 |pages=273–83 |year=2005 |pmid=16021123 |doi=10.1016/j.jaad.2004.10.006]

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Pyoderma gangrenosum — Classification et ressources externes Pyoderma gangrenosum sur la jambe d un patient atteint d une maladie de Crohn …   Wikipédia en Français

  • Pyoderma gangrenosum — An ulcerating condition of the skin leading to hollowed out areas (ulcers) with heaped up borders and a typical appearance. The lesion(s) usually begin as soft raised nodules on the skin which proceed to ulcerate. The ulcers enlarge and the skin… …   Medical dictionary

  • pyoderma gangrenosum — an acute destructive ulcerating process of the skin, especially the legs. It may be associated with ulcerative colitis or Crohn s disease or with rheumatoid arthritis or other forms of arthritis affecting many joints. Treatment is with… …   The new mediacal dictionary

  • Pyoderma — Classification and external resources ICD 10 L08.0 ICD 9 686.0 Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as …   Wikipedia

  • gangrenosum — see PYODERMA GANGRENOSUM …   Medical dictionary

  • Pyoderma gangraenosum — Klassifikation nach ICD 10 L88 Pyoderma gangraenosum Dermatitis ulcerosa …   Deutsch Wikipedia

  • Пиодермия Гангренозная (Pyoderma Gangrenosum) — острое деструктивное изъязвление кожи, особенно ног и лица. Может развиваться при наличии у больного язвенного колита, болезни Крона ревматоидного артрита или каких либо иных разновидностей артрита, при которых наблюдается поражение многих… …   Медицинские термины

  • pyoderma — Any pyogenic infection of the skin; may be primary, as impetigo, or secondary to a previously existing condition. [pyo + G. derma, skin] p. gangrenosum a chronic, noninfective eruption of spreading, undermined ulcers showing central healing, with …   Medical dictionary

  • malignant pyoderma — a destructive, progressive, ulcerative, suppurative skin disease resembling pyoderma gangrenosum, usually found on the head, neck, or trunk; it may develop spontaneously or at the site of trauma and then enlarge peripherally …   Medical dictionary

  • ПИОДЕРМИЯ ГАНГРЕНОЗНАЯ — (pyoderma gangrenosum) острое деструктивное изъязвление кожи, особенно ног и лица. Может развиваться при наличии у больного язвенного колита, болезни Крона ревматоидного артрита или каких либо иных разновидностей артрита, при которых наблюдается… …   Толковый словарь по медицине

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”