Vindesine

Vindesine

Systematic (IUPAC) name
methyl (5S,7S,9S)- 9-[(2β,3β,4β,5α,12β,19α)- 3-(aminocarbonyl)- 3,4-dihydroxy- 16-methoxy- 1-methyl- 6,7-didehydroaspidospermidin- 15-yl]- 5-ethyl- 5-hydroxy- 1,4,5,6,7,8,9,10-octahydro- 2H- 3,7-methanoazacycloundecino[5,4-b]indole- 9-carboxylate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	D(AU)
Legal status	℞ Prescription only
Routes	Intravenous
Pharmacokinetic data
Protein binding	65-75%
Metabolism	Hepatic (CYP3A4-mediated)
Half-life	24 hours
Excretion	Biliary and renal
Identifiers
CAS number	59917-39-4 Y
ATC code	L01CA03
PubChem	CID 40839
DrugBank	APRD00392
ChemSpider	37302 Y
UNII	RSA8KO39WH Y
KEGG	D01769 Y
ChEBI	CHEBI:36373 Y
ChEMBL	CHEMBL219146 Y
Chemical data
Formula	C43H55N5O7
Mol. mass	753.926 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1 Y Key:HHJUWIANJFBDHT-KOTLKJBCSA-N Y
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Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.^[1]

References

1. ^ Vindesine (Eldisine) : Cancerbackup

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Alkaloids Mitotic inhibitors Antineoplastic and immunomodulating drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Geoffrey Gates Masao Maruyama (scholar) Look at other dictionaries: vindesine — noun An antimitotic vinca alkaloid used in chemotherapy …   Wiktionary vindesine — Synthetic derivative of vinblastine which shares antineoplastic properties with the latter agent. Used in the treatment of childhood lymphocytic leukemia. * * * n. a vinca alkaloid with similarities to vinblastine and vincristine. Additional side …   Medical dictionary vindesine — n.; see vinca alkaloid …   The new mediacal dictionary vindesine — An anticancer drug that belongs to the family of plant drugs called vinca alkaloids …   English dictionary of cancer terms vindesine sulfate — vin·de·sine sul·fate (vinґdə sēn) a synthetic vinca alkaloid derived from vinblastine sulfate, used as an antineoplastic in the treatment of acute lymphoblastic leukemia and non–small cell carcinoma; administered intravenously …   Medical dictionary Виндезин (Vindesine) — цитотоксический лекарственный препарат, сходный с винбластином и винкристином. Помимо перечисленных ранее побочных эффектов в результате приема данного препарата у человека может развиться облысение и периферическая невропатия. Торговое название …   Медицинские термины ВИНДЕЗИН — (vindesine) цитотоксический лекарственный препарат, сходный с винбластином и винкристином. Помимо перечисленных ранее побочных эффектов в результате приема данного препарата у человека может развиться облысение и периферическая невропатия.… …   Толковый словарь по медицине Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia List of chemotherapeutic agents — This is a list of specific that are known to be of use in the treatment of cancer, otherwise known as . This list is organized by type of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is… …   Wikipedia Mitotic inhibitor — The structure of paclitaxel, a widely used mitotic inhibitor. A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the cell apart when it divides. Mitotic… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”