Uramustine

Uramustine

Systematic (IUPAC) name
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	5%
Excretion	Renal
Identifiers
CAS number	66-75-1 Y
ATC code	None
PubChem	CID 6194
DrugBank	APRD00130
UNII	W7KQ46GJ8U N
KEGG	D06265 Y
ChEMBL	CHEMBL1488 N
Chemical data
Formula	C8H11Cl2N3O2
Mol. mass	252.097 g/mol
N(what is this?)  (verify)

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Alkylating antineoplastic agents IARC Group 2B carcinogens Nitrogen mustards Pyrimidinediones Organochlorides Antineoplastic and immunomodulating drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? William Tranter Ontario Khalsa Darbar Look at other dictionaries: uramustine — noun A derivative of nitrogen mustard and uracil, used in chemotherapy as an alkylating agent. Syn: uracil mustard …   Wiktionary uramustine — SYN: uracil mustard …   Medical dictionary Урамустин (Uramustine) — цитотоксический лекарственный препарат; применяется для лечения различных видов злокачественных опухолей, особенно хронической лимфатической лейкемии. Урамустин назначается во внутривенных инъекциях и является высокотоксичным препаратом;… …   Медицинские термины УРАМУСТИН — (uramustine) цитотоксический лекарственный препарат; применяется для лечения различных видов злокачественных опухолей, особенно хронической лимфатической лейкемии. Урамустин назначается во внутривенных инъекциях и является высокотоксичным… …   Толковый словарь по медицине Nitrogen mustard — HN1 (bis(2 chloroethyl)ethylamine) …   Wikipedia Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia Paclitaxel — Systematic (IUPAC) name (2α,4α,5β,7β,10β,13α) 4,10 bis(acetyloxy) …   Wikipedia Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia Everolimus — Systematic (IUPAC) name dihydroxy 12 [(2R) 1 [(1S,3R,4R) 4 (2 hydroxyethoxy) 3 methoxycyclohexyl]propan 2 yl] 19,30 dimethoxy 15,17,21,23,29,35 hexamethyl 11,36 dioxa 4 azatricyclo[30.3.1.04,9]hexatriaconta 16,24,26,28 tetraene 2,3,10,14,20… …   Wikipedia Tretinoin — Systematic (IUPAC) name retinoic acid …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”