- Ixabepilone
Drugbox
IUPAC_name = (1"R",5"S",6"S",7"R",10"S",14"S",16"S")-6,10-dihydroxy-1,5,7,
9,9-pentamethyl-14- [("E")-1-(2-methyl-1,3-thiazol-
4-yl)prop-1-en-2-yl] -17-oxa-13-azabicyclo [14.1.0]
heptadecane-8,12-dione
width = 250
CAS_number = 219989-84-1
ATC_prefix = L01
ATC_suffix = DC04
PubChem = 6445540
DrugBank =
C=27|H=42|N=2|O=5|S=1
molecular_weight = 506.698 g/mol
smiles = C [C@H] 1CCC [C@@] 2( [C@@H] (O2)C [C@H] (NC(=O)C [C@@H] (C(C(=O) [C@@H] ( [C@H] 1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
synonyms = Azaepothilone B
bioavailability = N/A
protein_bound = 67 to 77%
metabolism = Extensive, hepatic,CYP3A4 -mediated
elimination_half-life = 52 hours
excretion = Fecal (mostly) and renal
licence_EU =
licence_US =
pregnancy_AU =
pregnancy_US = D
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US = Rx-only
legal_status =
routes_of_administration = Intravenous infusionIxabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is an
epothilone B analogcite journal |author=Goodin S |title=Novel cytotoxic agents: epothilones |journal=Am J Health Syst Pharm |volume=65 |issue=10 Suppl 3 |pages=S10–5 |year=2008 |month=May |pmid=18463327 |doi=10.2146/ajhp080089 |url=http://www.ajhp.org/cgi/pmidlookup?view=long&pmid=18463327] developed byBristol-Myers Squibb as a cancer drug.On October 16, 2007, the U.S.
Food and Drug Administration approved ixabepilone for the treatment of aggressive metastatic or locally advancedbreast cancer no longer responding to currently available chemotherapies. [ [http://www.medicalnewstoday.com/articles/85726.php Medical News Today] ] Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra.As of|September 2008, ixabepilone is not yet available in the
European Union .Clinical uses
Ixabepilone is indicated, in combination with
capecitabine for the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline and a taxane.References
External links
* [http://www.ixempra.com/ Ixempra product website]
* [http://packageinserts.bms.com/pi/pi_ixempra.pdf Ixempra prescribing information]
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