Pegaspargase

Pegaspargase

Systematic (IUPAC) name
Pegylated E. coli L-asparagine amidohydrolase
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a695031
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	130167-69-0 Y
ATC code	L01XX24
DrugBank	BTD00079
UNII	7D96IR0PPM Y
Chemical data
Formula	C1377H2208N382O442S17
Mol. mass	31731.9 g/mol
N(what is this?)  (verify)

Pegaspargase (pronounced /pəˈɡæspərɡeɪz/, trade name Oncaspar) is a modified enzyme used as an antineoplastic agent. It is a form of L-asparaginase^[1] which has undergone PEGylation.

It is used in the treatment of acute lymphoblastic leukemia.^[2][3]

References

1. ^ "UNM Cancer Center". http://cancer.unm.edu/drug_dictionary.aspx?id=818. Retrieved 2007-08-28. ^{[dead link]}
2. ^ Graham ML (2003). "Pegaspargase: a review of clinical studies". Adv. Drug Deliv. Rev. 55 (10): 1293–302. doi:10.1016/S0169-409X(03)00110-8. PMID 14499708. 
3. ^ Patel SS, Benfield P (Jun 1996). "New drug profile: pegaspargase (Polyethylene Glycol L-Asparaginase)". Clinical Immunotherapeutics 5 (6): 492–496. 

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