Pixantrone

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ImageFile=Pixantrone.svg
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IUPACName=6,9-bis [(2-aminoethyl)amino] benzo ["g"] isoquinoline-5,10-dione
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CASNo=144510-96-3
PubChem=134019
SMILES=C1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN
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Formula=C₁₇H₁₉N₅O₂
MolarMass=325.365 g/mol
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Pixantrone (rINN, codenamed BBR2778) is an immunosuppressant drug, an analogue of mitoxantrone with less toxic effects on cardiac tissue. It is being studied as an antineoplastic for different kinds of cancer, including solid tumors and hematological malignancies such as non-Hodgkin lymphomas.

It is also as potent as mitoxantrone in animal models of multiple sclerosis; however, results of human trials had not been published in 2007.cite journal |author=Gonsette RE, Dubois B |title=Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity |journal=J. Neurol. Sci. |volume=223 |issue=1 |pages=81–6 |year=2004 |pmid=15261566 |doi=10.1016/j.jns.2004.04.024]

As of 2007, several phase III clinical trials of pixantrone are underway. [ [http://clinicaltrials.gov/ct/show/NCT00088530 BBR 2778 for Relapsed, Aggressive Non-Hodgkin's Lymphoma (NHL).] ClinicalTrials.gov (2007-08-30). Retrieved on 2007-11-06.] [ [http://clinicaltrials.gov/ct/show/NCT00101049 Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma.] ClinicalTrials.gov (2007-10-25). Retrieved on 2007-11-06.] [ [http://clinicaltrials.gov/ct/show/NCT00551239 Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma.] ClinicalTrials.gov (2007-10-25). Retrieved on 2007-11-06.]

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