Lomustine

Lomustine

drugbox
IUPAC_name = 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea


CAS_number = 13010-47-4
ATC_prefix = L01
ATC_suffix = AD02
ATC_supplemental =
PubChem = 3950
DrugBank = APRD00292
C=9 | H=16 | Cl=1 | N=3 | O=2
molecular_weight = 233.695 g/mol
bioavailability =
protein_bound = 50%
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration = Oral

Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

Dose:

Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC) [Lexi-Comp Drug Information Handbook]

Dosage Form:

10mg, 40mg, 100mg Capsules

Other

It is the "C" in the "PCV" chemotherapy regimen.

References

External links

*
* [http://www.cancerbackup.org.uk/Treatments/Chemotherapy/Individualdrugs/Lomustine Patient information at cancerbackup.org.uk]
*


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Look at other dictionaries:

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