Satraplatin

Satraplatin

Drugbox
IUPAC_name = ("OC"-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum



CAS_number = 129580-63-8
ATC_prefix =
ATC_suffix =
PubChem = 123974
DrugBank =
C=10|H=22|Cl=2|N=2|O=4|Pt=1
molecular_weight = 500.277 g/mol
synonyms = BMY 45594BMS 182751bis-acetatoamminedichlorocyclohexylamine platinum(IV)
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral

Satraplatin (INN, codenamed JM216) is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, [cite journal |author=Kelland LR, Abel G, McKeage MJ, "et al" |title=Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug |journal=Cancer Res |volume=53 |issue=11 |pages=2581–6 |year=1993 |pmid=8388318 [http://cancerres.aacrjournals.org/cgi/reprint/53/11/2581.pdf?ijkey=75245aaa945af744674b85b6ae5d36a42c09477d Free full text] ] satraplatin is the first orally active platinum-based chemotherapeutic drug; [cite journal |author=Choy H, Park C, Yao M |title=Current status and future prospects for satraplatin, an oral platinum analogue |journal=Clin Cancer Res |volume=14 |issue=6 |pages=1633–8 |year=2008 |pmid=18347164 |doi=10.1158/1078-0432.CCR-07-2176] other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.

It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (Satraplatin Expanded Rapid Access).

The drug has also been used in the treatment of lung and ovarian cancers. The mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. [ [http://www.spectrumpharm.com/satraplatin.html Satraplatin - Spectrum Pharmaceuticals ] ]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Satraplatin — Strukturformel Allgemeines Freiname Satraplatin Andere Namen …   Deutsch Wikipedia

  • satraplatin — noun A particular drug used in chemotherapy …   Wiktionary

  • satraplatin — A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called platinum analogs. Also called BMS 182751 and JM 216 …   English dictionary of cancer terms

  • GPC Biotech — AG Unternehmensform Aktiengesellschaft Unternehmenssitz Martinsried/München …   Deutsch Wikipedia

  • Agennix — Dieser Artikel wurde aufgrund inhaltlicher und/oder formaler Mängel auf der Qualitätssicherungsseite des Portals Wirtschaft eingetragen. Du kannst helfen, indem Du die dort genannten Mängel beseitigst oder Dich an der Diskussion beteiligst …   Deutsch Wikipedia

  • Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia

  • Paclitaxel — Systematic (IUPAC) name (2α,4α,5β,7β,10β,13α) 4,10 bis(acetyloxy) …   Wikipedia

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

  • Everolimus — Systematic (IUPAC) name dihydroxy 12 [(2R) 1 [(1S,3R,4R) 4 (2 hydroxyethoxy) 3 methoxycyclohexyl]propan 2 yl] 19,30 dimethoxy 15,17,21,23,29,35 hexamethyl 11,36 dioxa 4 azatricyclo[30.3.1.04,9]hexatriaconta 16,24,26,28 tetraene 2,3,10,14,20… …   Wikipedia

  • Tretinoin — Systematic (IUPAC) name retinoic acid …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”