Alvocidib

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ImageFile=Alvocidib.pngImageSize=200px
IUPACName=2-(2-chlorophenyl)-5,7-dihydroxy-8- [(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl] -4-chromenone
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Section1=Chembox Identifiers
CASNo=
PubChem= 5287969
SMILES=CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
MeSHName = Flavopiridol
Section2=Chembox Properties
Formula=C₂₁H₂₀ClNO₅
MolarMass=401.8402
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Section3=Chembox Hazards
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Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. It has been studied also for the treatment of arthritis.cite journal |author=Sekine C, Sugihara T, Miyake S, "et al" |title=Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors |journal=J. Immunol. |volume=180 |issue=3 |pages=1954–61 |year=2008 |month=February |pmid=18209094 |doi= |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=18209094]

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Alvocidib

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