Vinflunine

Drugbox
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CAS_number = 162652-95-1
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PubChem = 6918295
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chemical_formula =
C=45 | H=54 | F=2 | N=4 | O=8
molecular_weight = 816.92 g/mol
smiles = CC [C@@] 12C=CCN3 [C@@H] 1 [C@] 4(CC3) [C@H] ( [C@] ( [C@@H] 2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45) [C@] 6(C [C@H] 7C [C@H] (CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C
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Vinflunine (INN) is a novel fluorinated Vinca alkaloidcite journal |author=Kruczynski A, Barret JM, Etiévant C, Colpaert F, Fahy J, Hill BT |title=Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid |journal=Biochem. Pharmacol. |volume=55 |issue=5 |pages=635–48 |year=1998 |month=March |pmid=9515574 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0006-2952(97)00505-4] undergoing research for the treatment of bladder cancer. It was originally discovered by the team of the Professor Jean-Claude Jacquesy (UMR CNRS 6514 - Poitiers University) [ Vinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor Derivatives Fahy, J.; Duflos, A.; Ribet, J.-P.; Jacquesy, J.-C.; Berrier, C.; Jouannetaud, M.-P.; Zunino, F.J. Am. Chem. Soc.; (Communication); 1997; 119(36); 8576-8577. ] , developed by Laboratoires Pierre Fabre and was licensed to Bristol-Myers Squibb for development in certain countries, including the United States.

On November 23, 2007, Pierre Fabre and BMS announced that they are terminating their license agreement for the development of vinflunine.cite web |url=http://newsroom.bms.com/article_display.cfm?article_id=5223 |title=Bristol -Myers Squibb press release - Bristol-Myers Squibb and Pierre Fabre Provide Update On Vinflunine Development Status |format= |work= |accessdate=2008-06-27]

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