Nelarabine

Nelarabine
Nelarabine
Systematic (IUPAC) name
(2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Clinical data
AHFS/Drugs.com monograph
Licence data EMA:Link, US FDA:link
Pregnancy cat. D(US)
Legal status ℞-only (US)
Routes Intravenous
Pharmacokinetic data
Bioavailability n/a
Protein binding <25%
Metabolism By adenosine deaminase, to 9-β-D-arabinofuranosylguanine
Half-life 30 minutes (nelarabine)
3 hours (ara-G)
Excretion Renal
Identifiers
CAS number 121032-29-9 YesY
ATC code L01BB07
PubChem CID 3011155
DrugBank DB01280
ChemSpider 2280207 YesY
UNII 60158CV180 YesY
KEGG D05134 N
ChEMBL CHEMBL1201112 N
Chemical data
Formula C11H15N5O5 
Mol. mass 297.268 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. It was previously known as 506U78.

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens. It was later approved in the European Union on August 22, 2007. Complete responses have been achieved with this medication.

It is marketed in the US as Arranon and as Atriance in the EU by GlaxoSmithKline.

External links


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Look at other dictionaries:

  • nelarabine — noun A particular drug used in chemotherapy. Syn: 506U78, compound …   Wiktionary

  • nelarabine — nel·ar·a·bine (nel arґə bēn) a prodrug of a purine nucleoside analog, used as an antimetabolite antineoplastic in treatment of T cell acute lymphoblastic leukemia and lymphoma that is relapsed or refractory to other regimens …   Medical dictionary

  • nelarabine — A drug used to treat certain types of T cell acute lymphoblastic leukemia (T ALL) and T cell lymphoblastic lymphoma (T LBL). It belongs to the family of drugs called antimetabolites. Also called 506U78 and Arranon …   English dictionary of cancer terms

  • List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia

  • List of health topics (0-9) — This is a list of health topics. NOTOC 1*1 aminocyclopentyl 1,3 dicarboxylate *1 azanaphthalene (Quinoline) *1 benzazine (Quinoline) *1 carbon compound *1 carbon transferase *1,12 (OH) D3 *1,12(OH)D3 *1,2 diazole *1,25 (OH) vitamin D *1,25… …   Wikipedia

  • 506U78 — noun Nelarabine …   Wiktionary

  • Arranon — Ar·ra·non (ārґə non) trademark for a preparation of nelarabine …   Medical dictionary

  • Жизненно необходимые и важнейшие лекарственные препараты — (ЖНВЛП; до 2011 года «ЖНВЛС», Жизненно необходимые и важнейшие лекарственные средства[1])  перечень лекарственных препаратов, утверждаемый Правительством Российской Федерации в целях государственного регулирования цен на лекарственные… …   Википедия

  • Arranon — A drug used to treat certain types of T cell acute lymphoblastic leukemia (T ALL) and T cell lymphoblastic lymphoma (T LBL). It belongs to the family of drugs called antimetabolites. Also called nelarabine and 506U78 …   English dictionary of cancer terms

  • 506U78 — A drug used to treat certain types of T cell acute lymphoblastic leukemia (T ALL) and T cell lymphoblastic lymphoma (T LBL). It belongs to the family of drugs called antimetabolites. Also called nelarabine and Arranon …   English dictionary of cancer terms

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