Estriol

Estriol
Identifiers
CAS number	50-27-1 Y
PubChem	5756
ChemSpider	5553 Y
UNII	FB33469R8E N
DrugBank	DB04573
KEGG	C05141 N
MeSH	Estriol
ChEBI	CHEBI:27974 N
ChEMBL	CHEMBL193482 N
Jmol-3D images	Image 1
SMILES Oc1cc3c(cc1)[C@H]2CC[C@@]4([C@@H](O)[C@H](O)C[C@H]4[C@@H]2CC3)C
InChI InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1 N Key: PROQIPRRNZUXQM-ZXXIGWHRSA-N N InChI=1/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1 Key: PROQIPRRNZUXQM-ZXXIGWHRBN
Properties
Molecular formula	C18H24O3
Molar mass	288.38
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Estriol (also oestriol) is one of the three main estrogens produced by the human body.

Synthesis

Human steroidogenesis, showing estriol at bottom right. In essence, it follows the pathway from dehydroepiandrosterone or DHEA (at left), but with a modified DHEA with an additional OH-group.

Estriol (E3) is only produced in significant amounts during pregnancy as it is made by the placenta from 16-Hydroxydehydroepiandrosterone sulfate (16-OH DHEAS),^[1] an androgen steroid made in the fetal liver and adrenal glands.

The human placenta produces pregnenolone and progesterone from circulating cholesterol. Pregnenolone is converted in the fetal adrenal gland into dehydroepiandrosterone (DHEA), a C19 steroid, then subsequently sulfonated to dehydroepiandrosterone sulfate (DHEAS). DHEAS is converted to 16-OH DHEAS in the fetal liver. The placenta converts 16-OH DHEAS to estriol, and is the predominant site of estriol synthesis.

Levels

Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.

Therapeutic use

In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably,^[2] according to researchers at UCLA's Geffen Medical School.

Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.^[3] Estriol may play a role in the development of breast cancer, but based on in vitro research does appear to act as an antagonist to the G-protein coupled estrogen receptor.^[4] Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. Though initial research in the 1970s suggested it could be used therapeutically as an estrogen, subsequent research failed to confirm this hypothesis.^[5][6]

Use in screening

Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and wellbeing. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the fetal liver.

If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test & quadruple test for antenatal screening for fetal anomalies.

Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false positives and false negatives in estriol testing for fetal distress include preeclampsia, anemia and impaired kidney function.^[7]

References

1. ^ Raju U, Bradlow HL, Levitz M (1990). "Estriol-3-sulfate in human breast cyst fluid. Concentrations, possible origin, and physiologic implications". Ann. N. Y. Acad. Sci. 586: 83–7. doi:10.1111/j.1749-6632.1990.tb17793.x. PMID 2141460. 
2. ^ Sicotte NL, Liva SM, Klutch R, Pfeiffer P, Bouvier S, Odesa S, Wu TC, Voskuhl RR (October 2002). "Treatment of multiple sclerosis with the pregnancy hormone estriol". Ann. Neurol. 52 (4): 421–8. doi:10.1002/ana.10301. PMID 12325070. 
3. ^ Melamed M, Castaño E, Notides AC, Sasson S (November 1997). "Molecular and kinetic basis for the mixed agonist/antagonist activity of estriol". Mol. Endocrinol. 11 (12): 1868–78. doi:10.1210/me.11.12.1868. PMID 9369454. 
4. ^ Lappano R, Rosano C, De Marco P, De Francesco EM, Pezzi V, Maggiolini M (May 2010). "Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells". Mol. Cell. Endocrinol. 320 (1-2): 162–70. doi:10.1016/j.mce.2010.02.006. PMID 20138962. 
5. ^ Sites CK (March 2008). "Bioidentical hormones for menopausal therapy". Women's Health (Lond Engl) 4 (2): 163–71. doi:10.2217/17455057.4.2.163. PMID 19072518. http://www.medscape.com/viewarticle/571299.  (free subscription required)
6. ^ Derzko, C (2009). "Bioidentical Hormone Therapy at Menopause" (pdf). Endocrinology Rounds 9 (6): 1–6. http://www.sigmamenopause.com/pdf/Derzko_BHT-Oct09.pdf. 
7. ^ Pagana TJ, Pagana KD (2009). Mosby's Manual of Diagnostic and Laboratory Tests. St. Louis: Mosby. pp. 240. ISBN 0-323-05747-0.