HMG-CoA

HMG-CoA

Chembox new
ImageFile=HMG coenzyme A.svg
ImageSize=300px
IUPACName=(9R,21S)-1- [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl] -3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide
OtherNames=
Section1= Chembox Identifiers
CASNo=1553-55-5
PubChem=84
SMILES=
MeSHName=HMG-CoA
Section2= Chembox Properties
Formula=C27H44N7O20P3S
MolarMass=911.661 g/mol
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the Mevalonate pathway. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase.

HMG-CoA reductase converts it into mevalonic acid.

Also, HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • HMG-CoA-Reduktase — Stäbchenmodell des Dimers mit Kalotten: Coenzym A (blau), β Hydroxy β methyl glutarylsäure (rot) und NADP (gr …   Deutsch Wikipedia

  • HMG-CoA-Synthase — Bezeichner Gen Name(n) …   Deutsch Wikipedia

  • HMG-CoA-Lyase — Vorhandene Strukturdaten: 2cw6 …   Deutsch Wikipedia

  • HMG-CoA reductasa — Enzima que controla la cantidad de síntesis de colesterol. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • HMG-CoA reductase — protein Name = 3 hydroxy 3 methylglutaryl Coenzyme A reductase caption = HMG CoA reductase width = 200 HGNCid = 5006 Symbol = HMGCR AltSymbols = EntrezGene = 3156 OMIM = 142910 RefSeq = NM 000859 UniProt = P04035 PDB = ECnumber = 1.1.1.88… …   Wikipedia

  • HMG-CoA-Reduktase-Hemmer — Als Statin wird im allgemeinen medizinischen Sprachgebrauch ein Arzneistoff bezeichnet, das der pharmakologischen Substanzklasse der 3 Hydroxy 3 Methylglutaryl Coenzym A Reduktase (HMG CoA Reduktase )Inhibitoren angehört. Da HMG CoA ein… …   Deutsch Wikipedia

  • HMG-CoA synthase — protein Name=3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) caption= width= HGNCid=5007 Symbol=HMGCS1 AltSymbols=HMGCS EntrezGene=3157 OMIM=142940 RefSeq=NM 002130 UniProt=Q01581 PDB= ECnumber=2.3.3.10 Chromosome=5 Arm=p Band=14… …   Wikipedia

  • HMG-CoA réductase — Cholestérol Cholestérol Structure du cholestérol Général Nom IUPAC 10,13 diméthyl 17 (6 méthylheptan 2 yl) 2,3,4,7,8,9,11,12,14,15 …   Wikipédia en Français

  • HMG-CoA reductase inhibitor — Hydroxymethylglutaryl coenzyme A reductase inhibitor. A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG CoA reductase inhibitor drugs are called statins. Also called… …   English dictionary of cancer terms

  • HMG-CoA — Abbreviation for β hydroxy β methylglutaryl CoA …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”