Ethisterone

Ethisterone

Drugbox
IUPAC_name = (8"R",9"S",10"R",13"R",14"S",17"R")-17-Ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1"H"-cyclopenta [a] phenanthren-3-one


CAS_number=434-03-7
ATC_prefix=G03
ATC_suffix=DC04
ATC_supplemental=
PubChem=11890120
DrugBank=
C = 21 | H = 28 | O = 2
molecular_weight = 312.446 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Ethisterone is a progestogen hormone.

The first orally active progestin, ethisterone (pregneninolone, 17α-ethynyltestosterone), the 17α-ethynyl analog of testosterone, was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin and marketed in Germany in 1939 as "Proluton C" and by Schering in the U.S. in 1945 as "Pranone".

Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel (Ciba, Organon, Roussel).

References

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* Kugener, André (2004). [http://www.kugener.com/abfrage.php?id=0081 Tabletten der Fa. Schering] ( [http://translate.google.com/translate?hl=en&sl=de&u=http://www.kugener.com/abfrage.php%3Fid%3D0081&sa=X&oi=translate&resnum=2&ct=result&prev=/search%3Fq%3Dproluton%2Bc%2B1939%26start%3D10%26hl%3Den%26rls%3Dcom.microsoft:en-US%26sa%3DN Tablets of Schering AG] ) "Proluton C" tablets circa 1939
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Look at other dictionaries:

  • ethisterone — An orally effective semisynthetic steroid that has biological effects similar to those of progesterone. SYN: ethindrone, pregneninolone. * * * ethis·ter·one i this tə .rōn n a synthetic orally effective female sex hormone C21H28O2 administered in …   Medical dictionary

  • ethisterone — ethis·ter·one …   English syllables

  • ethisterone — ə̇ˈthistəˌrōn noun ( s) Etymology: ethinyl + testosterone : a synthetic crystalline orally effective female sex hormone C21H28O2 administered in cases of deficiency of progesterone; 17 ethynyl testosterone called also anhydrohydroxyprogesterone …   Useful english dictionary

  • Этистерон (Ethisterone) — синтетический женский половой гормон (см. Прогестоген), применяется (часто в сочетании с эстрогеном) для лечения нарушений менструального цикла, главным образом аменореи. Ранее использовался для тестирования на наличие у женщины беременности по… …   Медицинские термины

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  • Progestin-induced virilisation — Maternal use of androgens or high doses of certain weakly androgenic synthetic progestogens (progestins) structurally related to testosterone can masculinize (virilize) the external genitalia of a female fetus during susceptible times in… …   Wikipedia

  • Progestin — Co inventor Luis E. Miramontes s signed laboratory notebook. October 15, 1951 A progestin is a synthetic[1] progestogen that has progestinic effects similar to progesterone. [2] …   Wikipedia

  • ATC code G03 — A section of the Anatomical Therapeutic Chemical Classification System.G Genito urinary system and sex hormonesG03A Hormonal contraceptives for systemic useG03AA Progestogens and estrogens, fixed combinations:G03AA01 Etynodiol and… …   Wikipedia

  • pregneninolone — SYN: ethisterone. * * * preg·nen·in·o·lone .preg nen in əl .ōn n ETHISTERONE …   Medical dictionary

  • Djerassi , Carl — (1923–) American chemist Djerassi was born in the Austrian capital of Vienna, the son of a Bulgarian physician and an Austrian mother. As both parents were Jewish, Djerassi emigrated to America in 1939. He was educated at Kenyon College, Ohio,… …   Scientists

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