- Etonogestrel
drugbox
IUPAC_name = (8"S",9"R",10"S",13"S",14"S",17"R")-13-Ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1"H"-cyclopenta [a] phenanthren-3-one
CAS_number = 54048-10-1
ATC_prefix = G03
ATC_suffix = AC08
ATC_supplemental =
PubChem = 21729469
DrugBank = APRD00766
C = 22 | H = 28 | O = 2
molecular_weight = 324.457 g/mol
bioavailability =
protein_bound =
metabolism = Hepatic (P450 3A4)
elimination_half-life = 25 hours
excretion = Urinary (majority) and fecal
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU = S4
legal_UK = POM
legal_US = Rx-only
legal_status = Rx-only
routes_of_administration = Subdermal as slow-release implantEtonogestrel is a molecule used in
hormonal contraceptives , most notably the subdermal implantImplanon .Etonogestrel, the specific progestin used in NuvaRing, is the active metabolite of the inactive prodrug desogestrel, one of two third-generation progestins found in some epidemiological studies of combined oral contraceptive pills to be associated with a higher risk of venous thrombosis than combined oral contraceptive pills containing certain second-generation progestins. Because hormones are released continuously from NuvaRing, peak and total estrogen and progestin doses are significantly lower than with combined oral contraceptives, although it is not known whether this lowers the risk of blood clots.
ee also
*
Progestin
*Progestagen
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