CDB-4124

CDB-4124

Drugbox
IUPAC_name = 17α-acetoxy-21-methoxy-11β- [4-N,N-dimethylaminophenyl] -19-norpregna-4,9-diene-3,20-dione)



CAS_number = 136960-00-4
CAS_supplemental =
ATC_prefix =
ATC_suffix =
ATC_supplemental =
PubChem = 9577221
DrugBank =
chemical_formula =
C=31 | H=39 | N=1 | O=5
molecular_weight = 505.65 g/mol
smiles =
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Investigational
routes_of_administration =

CDB-4124 (proposed trade names Proellex, Progenta) is an investigational selective progesterone receptor modulator, tested for treatment of progesterone sensitive myomata. [cite journal |author=Attardi BJ, Burgenson J, Hild SA, Reel JR |title=In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone |journal=J Steroid Biochem Mol Biol |volume=88 |issue=3 |pages=277–88 |year=2004 |pmid= 15120421 |doi = 10.1016/j.jsbmb.2003.12.004 ]

as of|September 2008, it is undergoing Phase II and III clinical trials. [ [http://www.clinicaltrials.gov/ct2/results?term=Proellex ClinicalTrials.gov] ]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • CDB — can refer to:In music: * CDB (band), an Australian band * Charlie Daniels Band, the band of American musician Charlie DanielsIn organizations: * Caribbean Development Bank, an international financial institution * China Development Bank, a… …   Wikipedia

  • Selective progesterone receptor modulator — A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor. A characteristic that distinguishes such substances from receptor full agonists (such as progesterone) and full antagonists (such as RU 486) is …   Wikipedia

  • Estrogen — Estriol. Note two hydroxyl ( OH) groups attached to the D ring (rightmost ring) …   Wikipedia

  • Progesterone — Systematic (IUPAC) name Pregn 4 ene 3,20 dione …   Wikipedia

  • Mifepristone — Systematic (IUPAC) name 11β [p (Dimethylamino)phenyl] 17β hyd …   Wikipedia

  • Estradiol — Not to be confused with 17α estradiol. Estradiol Systematic (IUPAC) name …   Wikipedia

  • Progestin — Co inventor Luis E. Miramontes s signed laboratory notebook. October 15, 1951 A progestin is a synthetic[1] progestogen that has progestinic effects similar to progesterone. [2] …   Wikipedia

  • Diethylstilbestrol — Systematic (IUPAC) name 4,4 (3E) hex 3 ene 3,4 diyldiphenol Clinical data AHFS/Drugs.com …   Wikipedia

  • Estrone — Systematic (IUPAC) name 3 hydroxy 13 methyl 6,7,8,9,11,12,13,14,15,16 decahydrocyclopenta[a]p …   Wikipedia

  • Estriol — Identifiers CAS number …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”