Cyclofenil

Cyclofenil
Not to be confused with Cycloguanil.
Cyclofenil
Systematic (IUPAC) name
[4-[(4-acetoxyphenyl)-cyclohexylidene-methyl]phenyl] acetate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Identifiers
CAS number 5189-40-2
ATC code G03GB01
PubChem CID 2898
ChemSpider 2795
UNII J468V64WZ1 YesY
KEGG D01281
Synonyms bis(p-acetoxyphenyl)cyclohexylidenemethane
Chemical data
Formula C23H24O4 
Mol. mass 364.434 g/mol
SMILES eMolecules & PubChem

Cyclofenil (INN, trade names Ondogyne, Sexovid, and others) is a selective estrogen receptor modulator.

It was investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective.[1] Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.[2]

References

  1. ^ Torres MA, Furst DE (February 1990). "Treatment of generalized systemic sclerosis". Rheum Dis Clin North Am 16 (1): 217–41. PMID 2406809. 
  2. ^ Pope J, Fenlon D, Thompson A, et al. (2000). Pope, Janet. ed. "Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database Syst Rev (2): CD000955. doi:10.1002/14651858.CD000955. PMID 10796397. 
v · d · eEstrogens and progestogens (G03C-D, L02)
Progestogens/
progestins
(progesterone)
Agonist
Androstene (Drospirenone) • 19-norprogesterone (Nomegestrol • Promegestone • Trimegestone) • 19-nortestosterone (Dienogest)
Other/
ungrouped
Pregnenedione (Gestonorone) • Pregnene (Ethisterone) • Pregnadiene (Medrogestone • Melengestrol) • Norpregnane (Norgestrienone) • Lynestrenol • Norethynodrel • Tibolone • Dydrogesterone • Quingestanol
antagonist: Mifepristone
Asoprisnil • CDB-4124  • Ulipristal acetate
Estrogens
Agonist
Diosgenin • Estradiol (Ethinylestradiol#/Mestranol • Estradiol 17 beta-cypionate# • Polyestradiol phosphate) • Estrone (Estrone sulfate) • Estriol • Promestriene • Equilenin • Equilin
Afimoxifene • Arzoxifene • Bazedoxifene • Cyclofenil • Lasofoxifene • Ormeloxifene • Raloxifene • Tamoxifen • Toremifene
pure antagonist: Fulvestrant
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: ♀ FRS

anat/phys/devp

noco/cong/npls, sysi/epon

proc/asst, drug (G1/G2B/G3CD)


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