Asoprisnil

Asoprisnil

Drugbox
IUPAC_name = rel-4- [(8R,11S,13R,14R,17R)-17-Methoxy-17-(methoxymethyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta [a] phenanthren-11-yl] benzaldehyde oxime



CAS_number = 199396-76-4
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PubChem = 9577221
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chemical_formula =
C=28 | H=35 | N=1 | O=4
molecular_weight = 449.582 g/mol
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Asoprisnil (J867) is an investigational selective progesterone receptor modulator developed by Schering and TAP Pharmaceutical Products, tested for treatment of progesterone sensitive myomata. [cite journal |author=DeManno D, Elger W, Garg R, "et al" |title=Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy |journal=Steroids |volume=68 |issue=10-13 |pages=1019–32 |year=2003 |pmid=14667995 |doi=]

In 2005, Phase III trials were discontinued due to endometrial changes in patients. It is uncertain whether asoprisnil will be marketed. [ [http://www.schering.de/html/en/50_media/download/_files/2005/fin_rep/interim/05q3_areas_en.pdf Schering Interim Report Q1-3 2005] ]

References


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