Acetoacetyl-CoA

Acetoacetyl-CoA

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ImageFile=Acetoacetyl coenzyme A.svg
ImageSize=300px
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Section1= Chembox Identifiers
CASNo=1420-36-6
PubChem=74
SMILES=
MeSHName=acetoacetyl+CoA
Section2= Chembox Properties
Formula=C25H40N7O18P3S
MolarMass=851.609 g/mol
Appearance=
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Section3= Chembox Hazards
MainHazards=
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Acetoacetyl CoA is the precursor of HMG-CoA in the the Mevalonate pathway which is essential for cholesterol synthesis. It also takes a similar role in the ketone bodies synthesis pathway of the liver. In the ketone bodies digestion pathway (in the tissue) it is no longer associated with having HMG-CoA as a product or as a reactant.

It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. (During the metabolism of leucine, this last reaction is reversed.)

ee also

* Beta-hydroxybutyryl-CoA dehydrogenase


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Look at other dictionaries:

  • acetoacetyl-CoA — Intermediate in the oxidation of fatty acid s and in the formation of ketone bodies; also formed from two molecules of acetyl CoA; major role is condensation with acetyl CoA to form the important β hydroxy β methylglutaryl CoA. SYN: acetoacetyl …   Medical dictionary

  • Acetoacetyl-CoA hydrolase — In enzymology, an acetoacetyl CoA hydrolase (EC number|3.1.2.11) is an enzyme that catalyzes the chemical reaction:acetoacetyl CoA + H2O ightleftharpoons CoA + acetoacetateThus, the two substrates of this enzyme are acetoacetyl CoA and H2O,… …   Wikipedia

  • Acetoacetyl-CoA reductase — In enzymology, an acetoacetyl CoA reductase (EC number|1.1.1.36) is an enzyme that catalyzes the chemical reaction:(R) 3 hydroxyacyl CoA + NADP+ ightleftharpoons 3 oxoacyl CoA + NADPH + H+Thus, the two substrates of this enzyme are (R) 3… …   Wikipedia

  • acetoacetyl CoA — ac·e·to·ac·e·tyl CoA (as″ə to asґə təl) (ə seґto as ə tēl″ ko aґ) acetoacetyl coenzyme A …   Medical dictionary

  • acetoacetyl CoA thiolase — ac·e·to·ac·e·tyl CoA thi·o·lase (as″ə to asґə təl) (ə seґto as ə tēl″ ko aґ thiґo lās) acetyl CoA C acetyltransferase …   Medical dictionary

  • acetoacetyl-CoA reductase — ac·e·to·ac·e·tyl CoA re·duc·tase (as″ə to asґə təl) (ə seґto as ə tēl″ ko aґ re duk tās) [EC 1.1.1.36] an enzyme of the oxidoreductase class that catalyzes the reduction of 3 ketoacyl coenzyme A to 3 …   Medical dictionary

  • Acétoacétyl-coenzyme A — Structure de l acétoacétyl coenzyme A Général No CAS …   Wikipédia en Français

  • acetoacetyl-coenzyme A — SYN: acetoacetyl CoA …   Medical dictionary

  • acetoacetyl coenzyme A — ac·e·to·ac·e·tyl co·en·zyme A (as″ə to asґə təl) (ə seґto as ə tēl″ ko enґzīm) a thioester of acetoacetic acid and coenzyme A. It is an important metabolic intermediate in the oxidation of fatty… …   Medical dictionary

  • acetoacetyl-succinic thiophorase — SYN: 3 oxoacid CoA transferase …   Medical dictionary

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