Lanosterol 14 alpha-demethylase

cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
Symbol	CYP51A1
Alt. symbols	CYP51, P45014DM
Entrez	1595
HUGO	2649
OMIM	601637
RefSeq	NM_000786
UniProt	Q16850
Other data
EC number	1.14.13.70
Locus	Chr. 7 q21.2-21.3

Lanosterol 14 α-demethylase (or CYP51A1, P45014DM) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) enzyme that converts lanosterol to cholesterol.

It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.^[1]

• 

  Lanosterol

• 

  Ergosterol

• 

  Cholesterol

See also

• Antifungal drug

References

1. ^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). "Antifungal drug resistance in pathogenic fungi". Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500. 

External links

• MeSH cytochrome+P-450+CYP51

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase
7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase
Desmosterol path	24-dehydrocholesterol reductase

To Bile acids

Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase

Steroidogenesis

To pregnenolone	Side-chain cleavage
To corticosteroids	aldosterone: 18-hydroxylase cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2) both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase
To sex hormones	To androgens 17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase (1,2) To estrogens Aromatase
Other/ungrouped	Steroid metabolism: sulfatase (Steroid sulfatase) · sulfotransferase (SULT1A1, SULT2A1) Steroidogenic acute regulatory protein

M: MET mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END anat/phys/devp/horm noco(d)/cong/tumr, sysi/epon proc, drug (A10/H1/H2/H3/H5)