CYP4F3

CYP4F3

Cytochrome P450, family 4, subfamily F, polypeptide 3, also known as CYP4F3, is a human gene.cite web | title = Entrez Gene: CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4051| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away.cite web | title = Entrez Gene: CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4051| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Simpson AE |title=The cytochrome P450 4 (CYP4) family. |journal=Gen. Pharmacol. |volume=28 |issue= 3 |pages= 351–9 |year= 1997 |pmid= 9068972 |doi=
*cite journal | author=Kikuta Y, Kusunose E, Kondo T, "et al." |title=Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver. |journal=FEBS Lett. |volume=348 |issue= 1 |pages= 70–4 |year= 1994 |pmid= 8026587 |doi=
*cite journal | author=Kikuta Y, Kusunose E, Endo K, "et al." |title=A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase. |journal=J. Biol. Chem. |volume=268 |issue= 13 |pages= 9376–80 |year= 1993 |pmid= 8486631 |doi=
*cite journal | author=Kikuta Y, Kato M, Yamashita Y, "et al." |title=Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. |journal=DNA Cell Biol. |volume=17 |issue= 3 |pages= 221–30 |year= 1998 |pmid= 9539102 |doi=
*cite journal | author=Christmas P, Ursino SR, Fox JW, Soberman RJ |title=Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. |journal=J. Biol. Chem. |volume=274 |issue= 30 |pages= 21191–9 |year= 1999 |pmid= 10409674 |doi=
*cite journal | author=Christmas P, Jones JP, Patten CJ, "et al." |title=Alternative splicing determines the function of CYP4F3 by switching substrate specificity. |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 38166–72 |year= 2001 |pmid= 11461919 |doi= 10.1074/jbc.M104818200
*cite journal | author=Christmas P, Carlesso N, Shang H, "et al." |title=Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 25133–42 |year= 2003 |pmid= 12709424 |doi= 10.1074/jbc.M302106200
*cite journal | author=Mizukami Y, Sumimoto H, Takeshige K |title=Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 1 |pages= 104–9 |year= 2004 |pmid= 14715252 |doi=
*cite journal | author=Christmas P, Tolentino K, Primo V, "et al." |title=Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4. |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 7189–96 |year= 2006 |pmid= 16380383 |doi= 10.1074/jbc.M513101200

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