SRD5A1

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), also known as SRD5A1, is a human gene.

PBB_Summary
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summary_text = Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). There are 2 isoforms of the enzyme: SRD5A1 and SRD5A2 (MIM 607306). [supplied by OMIM] cite web | title = Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6715| accessdate = ]

ee also

* 5-alpha reductase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jenkins EP, Andersson S, Imperato-McGinley J, "et al." |title=Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase. |journal=J. Clin. Invest. |volume=89 |issue= 1 |pages= 293–300 |year= 1992 |pmid= 1345916 |doi=
*cite journal | author=Jenkins EP, Hsieh CL, Milatovich A, "et al." |title=Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. |journal=Genomics |volume=11 |issue= 4 |pages= 1102–12 |year= 1992 |pmid= 1686016 |doi=
*cite journal | author=Andersson S, Russell DW |title=Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 10 |pages= 3640–4 |year= 1990 |pmid= 2339109 |doi=
*cite journal | author=Moore RJ, Wilson JD |title=Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate. |journal=J. Biol. Chem. |volume=247 |issue= 3 |pages= 958–67 |year= 1972 |pmid= 4400474 |doi=
*cite journal | author=Milewich L, Kaimal V, Toews GB |title=Androstenedione metabolism in human alveolar macrophages. |journal=J. Clin. Endocrinol. Metab. |volume=56 |issue= 5 |pages= 920–4 |year= 1983 |pmid= 6833469 |doi=
*cite journal | author=Thigpen AE, Silver RI, Guileyardo JM, "et al." |title=Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. |journal=J. Clin. Invest. |volume=92 |issue= 2 |pages= 903–10 |year= 1993 |pmid= 7688765 |doi=
*cite journal | author=Antonipillai I, Wahe M, Yamamoto J, Horton R |title=Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts. |journal=Mol. Cell. Endocrinol. |volume=107 |issue= 1 |pages= 99–104 |year= 1995 |pmid= 7796940 |doi=
*cite journal | author=Hirsch KS, Jones CD, Audia JE, "et al." |title=LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 11 |pages= 5277–81 |year= 1993 |pmid= 8389478 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Bonkhoff H, Stein U, Aumüller G, Remberger K |title=Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas. |journal=Prostate |volume=29 |issue= 4 |pages= 261–7 |year= 1996 |pmid= 8876709 |doi= 10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO;2-E |doilabel=10.1002/(SICI)1097-0045(199610)29:4261::AID-PROS73.0.CO;2-E
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Ellis JA, Stebbing M, Harrap SB |title=Genetic analysis of male pattern baldness and the 5alpha-reductase genes. |journal=J. Invest. Dermatol. |volume=110 |issue= 6 |pages= 849–53 |year= 1998 |pmid= 9620288 |doi= 10.1046/j.1523-1747.1998.00224.x
*cite journal | author=Zhou Z, Shackleton CH, Pahwa S, "et al." |title=Prominent sex steroid metabolism in human lymphocytes. |journal=Mol. Cell. Endocrinol. |volume=138 |issue= 1-2 |pages= 61–9 |year= 1998 |pmid= 9685215 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Eminović I, Liović M, Prezelj J, "et al." |title=New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8. |journal=Pflugers Arch. |volume=442 |issue= 6 Suppl 1 |pages= R187–9 |year= 2002 |pmid= 11678334 |doi=
*cite journal | author=Ellis JA, Wong ZY, Stebbing M, Harrap SB |title=Sex, genes and blood pressure. |journal=Clin. Exp. Pharmacol. Physiol. |volume=28 |issue= 12 |pages= 1053–5 |year= 2002 |pmid= 11903314 |doi=
*cite journal | author=Rodríguez-Dorantes M, Lizano-Soberón M, Camacho-Arroyo I, "et al." |title=Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 3 |pages= 323–30 |year= 2002 |pmid= 11948017 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ha SJ, Kim JS, Myung JW, "et al." |title=Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. |journal=J. Dermatol. Sci. |volume=31 |issue= 2 |pages= 135–41 |year= 2003 |pmid= 12670724 |doi=
*cite journal | author=Habib FK, Ross M, Bayne CW, "et al." |title=The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1815–9 |year= 2004 |pmid= 12738739 |doi=

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