CYP2C18

Cytochrome P450, family 2, subfamily C, polypeptide 18, also known as CYP2C18, is a human gene.cite web | title = Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1562| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP4218 and CYP2C19.cite web | title = Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1562| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285–99 |year= 1995 |pmid= 7704034 |doi=
*cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=
*cite journal | author=Ged C, Beaune P |title=Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene. |journal=Pharmacogenetics |volume=2 |issue= 3 |pages= 109–15 |year= 1993 |pmid= 1306110 |doi=
*cite journal | author=Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ |title=Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. |journal=Mol. Pharmacol. |volume=40 |issue= 3 |pages= 375–82 |year= 1991 |pmid= 1896026 |doi=
*cite journal | author=Romkes M, Faletto MB, Blaisdell JA, "et al." |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. |journal=Biochemistry |volume=30 |issue= 13 |pages= 3247–55 |year= 1991 |pmid= 2009263 |doi=
*cite journal | author=Romkes M, Faletto MB, Blaisdell JA, "et al." |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily. |journal=Biochemistry |volume=32 |issue= 5 |pages= 1390 |year= 1993 |pmid= 8095407 |doi=
*cite journal | author=Goldstein JA, Faletto MB, Romkes-Sparks M, "et al." |title=Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. |journal=Biochemistry |volume=33 |issue= 7 |pages= 1743–52 |year= 1994 |pmid= 8110777 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=de Morais SM, Schweikl H, Blaisdell J, Goldstein JA |title=Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 1 |pages= 194–201 |year= 1993 |pmid= 8333835 |doi=
*cite journal | author=Richardson TH, Griffin KJ, Jung F, "et al." |title=Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. |journal=Arch. Biochem. Biophys. |volume=338 |issue= 2 |pages= 157–64 |year= 1997 |pmid= 9028867 |doi= 10.1006/abbi.1996.9817
*cite journal | author=Zaphiropoulos PG |title=Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 2985–93 |year= 1997 |pmid= 9154796 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Macé K, Bowman ED, Vautravers P, "et al." |title=Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. |journal=Eur. J. Cancer |volume=34 |issue= 6 |pages= 914–20 |year= 1998 |pmid= 9797707 |doi=
*cite journal | author=Klose TS, Blaisdell JA, Goldstein JA |title=Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. |journal=J. Biochem. Mol. Toxicol. |volume=13 |issue= 6 |pages= 289–95 |year= 1999 |pmid= 10487415 |doi=
*cite journal | author=Finta C, Zaphiropoulos PG |title=The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. |journal=Genomics |volume=63 |issue= 3 |pages= 433–8 |year= 2000 |pmid= 10704292 |doi= 10.1006/geno.1999.6063
*cite journal | author=Thum T, Borlak J |title=Gene expression in distinct regions of the heart. |journal=Lancet |volume=355 |issue= 9208 |pages= 979–83 |year= 2000 |pmid= 10768437 |doi=
*cite journal | author=Marill J, Cresteil T, Lanotte M, Chabot GG |title=Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1341–8 |year= 2001 |pmid= 11093772 |doi=
*cite journal | author=Zhu-Ge J, Yu YN, Qian YL, Li X |title=Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing. |journal=World J. Gastroenterol. |volume=8 |issue= 5 |pages= 888–92 |year= 2003 |pmid= 12378636 |doi=

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