CYP4F2

Cytochrome P450, family 4, subfamily F, polypeptide 2, also known as CYP4F2, is a human gene.cite web | title = Entrez Gene: CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8529| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.cite web | title = Entrez Gene: CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8529| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Simpson AE |title=The cytochrome P450 4 (CYP4) family. |journal=Gen. Pharmacol. |volume=28 |issue= 3 |pages= 351–9 |year= 1997 |pmid= 9068972 |doi=
*cite journal | author=Kikuta Y, Kusunose E, Kondo T, "et al." |title=Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver. |journal=FEBS Lett. |volume=348 |issue= 1 |pages= 70–4 |year= 1994 |pmid= 8026587 |doi=
*cite journal | author=Chen L, Hardwick JP |title=Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. |journal=Arch. Biochem. Biophys. |volume=300 |issue= 1 |pages= 18–23 |year= 1993 |pmid= 8424651 |doi=
*cite journal | author=Powell PK, Wolf I, Jin R, Lasker JM |title=Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. |journal=J. Pharmacol. Exp. Ther. |volume=285 |issue= 3 |pages= 1327–36 |year= 1998 |pmid= 9618440 |doi=
*cite journal | author=Kikuta Y, Miyauchi Y, Kusunose E, Kusunose M |title=Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene. |journal=DNA Cell Biol. |volume=18 |issue= 9 |pages= 723–30 |year= 1999 |pmid= 10492403 |doi= 10.1089/104454999315006
*cite journal | author=Lasker JM, Chen WB, Wolf I, "et al." |title=Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4118–26 |year= 2000 |pmid= 10660572 |doi=
*cite journal | author=Zhang X, Chen L, Hardwick JP |title=Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells. |journal=Arch. Biochem. Biophys. |volume=378 |issue= 2 |pages= 364–76 |year= 2000 |pmid= 10860554 |doi= 10.1006/abbi.2000.1836
*cite journal | author=Zhang X, Hardwick JP |title=Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 864–71 |year= 2001 |pmid= 11162441 |doi= 10.1006/bbrc.2000.4020
*cite journal | author=Peng X, Pan X, Kenga M |title= [Isolation and sequencing of a novel form of cytochrome p-450 4F family from human liver] |journal=Zhonghua Yi Xue Za Zhi |volume=79 |issue= 11 |pages= 860–2 |year= 2002 |pmid= 11715494 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nagata T, Takahashi Y, Ishii Y, "et al." |title=Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 713–21 |year= 2004 |pmid= 12736711 |doi=
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hsu MH, Savas U, Griffin KJ, Johnson EF |title=Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. |journal=J. Biol. Chem. |volume=282 |issue= 8 |pages= 5225–36 |year= 2007 |pmid= 17142457 |doi= 10.1074/jbc.M608176200
*cite journal | author=Sontag TJ, Parker RS |title=Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase. |journal=J. Lipid Res. |volume=48 |issue= 5 |pages= 1090–8 |year= 2007 |pmid= 17284776 |doi= 10.1194/jlr.M600514-JLR200
*cite journal | author=Stec DE, Roman RJ, Flasch A, Rieder MJ |title=Functional polymorphism in human CYP4F2 decreases 20-HETE production. |journal=Physiol. Genomics |volume=30 |issue= 1 |pages= 74–81 |year= 2007 |pmid= 17341693 |doi= 10.1152/physiolgenomics.00003.2007

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