Acenocoumarol

Acenocoumarol

Systematic (IUPAC) name
(RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	X
Legal status	POM (UK)
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	8 to 11 hours
Identifiers
CAS number	152-72-7 Y
ATC code	B01AA07
PubChem	CID 9052
DrugBank	DB01418
ChemSpider	10443441 Y
UNII	I6WP63U32H Y
KEGG	D07064 Y
ChEBI	CHEBI:53766 Y
ChEMBL	CHEMBL397420 Y
Chemical data
Formula	C19H15NO6
Mol. mass	353.326 g·mol-1
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3 Y Key:VABCILAOYCMVPS-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

Dosage

Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the right dosage. Acenocoumarol is contraindicated during pregnancy.

External links

• DDB 29202
• Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922. 
• Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697. 
• Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822. 
• Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310. 

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.v · Categories: Vitamin K antagonists Nitrobenzenes Coumarin drugs Ketones Blood and blood forming organ drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Black Hawk War (disambiguation) Austrochiloidea Look at other dictionaries: Acénocoumarol — Général Nom IUPAC (RS) 4 hydroxy 3 [1 (4 nitrophenyl) 3 oxobutyl] 2H chromèn 2 one …   Wikipédia en Français acénocoumarol — ● acénocoumarol nom masculin Anticoagulant dérivé de la coumarine et doué d une action antivitaminique K …   Encyclopédie Universelle acenocoumarol — An orally effective synthetic anticoagulant of the coumarin type, with similar actions. SYN: acenocoumarin, nicoumalone. * * * ace·no·cou·ma·rol (ə se″no kooґmə rol) a coumarin derivative used as an oral anticoagulant; it acts by… …   Medical dictionary 152-72-7 — Acénocoumarol Acénocoumarol Général Nom IUPAC 4 hydroxy 3 [1 (4 nitrophenyl) 3 oxobutyl] 2H chromen 2 one N …   Wikipédia en Français C19H15NO6 — Acénocoumarol Acénocoumarol Général Nom IUPAC 4 hydroxy 3 [1 (4 nitrophenyl) 3 oxobutyl] 2H chromen 2 one N …   Wikipédia en Français Sintrom — Acénocoumarol Acénocoumarol Général Nom IUPAC 4 hydroxy 3 [1 (4 nitrophenyl) 3 oxobutyl] 2H chromen 2 one N …   Wikipédia en Français Acenocumarol — Strukturformel 1:1 Gemisch (Racemat) Allgemeines …   Deutsch Wikipedia Acenocumarol — Nombre (IUPAC) sistemático (RS) 2 hydroxy 3 [1 (4 nitrophenyl) 3 oxobutyl] 4H …   Wikipedia Español Warfarin — This article is about the drug with the brandname Coumadin. For the anticoagulant rodenticide poisons often called coumarins or coumadins , see 4 hydroxycoumarins. Warfarin …   Wikipedia Anticoagulant — An anticoagulant is a substance that prevents coagulation (clotting) of blood. A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombotic disorders. Some anticoagulants are used in medical equipment, such… …   Wikipedia 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”